DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and Grin2b

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001350679.1	Gene:	Grin2b / 14812	MGIID:	95821	Length:	1482	Species:	Mus musculus

Alignment Length:	1034	Identity:	305/1034 - (29%)
Similarity:	489/1034 - (47%)	Gaps:	183/1034 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 LKDYSFEQKNIHFDMMSLTP----------SPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTA 193
            :|| :.|:.:.|.  :|:.|          .|.:|::.:|.......:..:::..:.:|    .|
Mouse    50 IKD-AHEKDDFHH--LSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQ----EA 107

  Fly   194 SAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVV 258
            .||....::.....|::..:..:|.:.....:|::..|..||||.|::.||:|:|.|.|:.||:|
Mouse   108 IAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV 172

  Fly   259 TSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLM---------------ELVNSEAR 308
            |:...|:.|||..:|.           ||.||.|.....:::               :|...::.
Mouse   173 TTYFPGYQDFVNKIRS-----------TIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSP 226

  Fly   309 VMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKD-AHSQFPVGMLGVHFDTSSAALMN 372
            ::|||.|:.||..|...|..:.|||..|.|:|...|....| ..|:||.|::.|.:|.....|..
Mouse   227 IILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPA 291

  Fly   373 EISNAIKIYSYGV------EAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEG 431
            .:.:.|.|.:...      .:::.:|.:          ||.:....|.....:..:||.||:.||
Mouse   292 RVRDGIAIITTAASDMLSEHSFIPEPKS----------SCYNTHEKRIYQSNMLNRYLINVTFEG 346

  Fly   432 DLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPP 496
                .|:.|:.||.....:|.|:.|     ||...||.:|.||.   :.|.::...||  ...|.
Mouse   347 ----RNLSFSEDGYQMHPKLVIILL-----NKERKWERVGKWKD---KSLQMKYYVWP--RMCPE 397

  Fly   497 QGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQ 561
            ....|..||.|..|||||::.:...||:||.| |...|.|:.....|...|.:.|...:
Mouse   398 TEEQEDDHLSIVTLEEAPFVIVESVDPLSGTC-MRNTVPCQKRIISENKTDEEPGYIKK------ 455

  Fly   562 CCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTERE 626
            ||.|||||:|:|.::.:.|||:|..|.:||.|...||.|||:|.::|.::..|.:.||.||.||.
Mouse   456 CCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERS 520

  Fly   627 AVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGY 691
            .|||||.||:||||:::|::..|.:||:||||||....|:::.::.:..:...:|:||:.||.||
Mouse   521 EVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY 585

  Fly   692 DMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTAN 756
            :..|........| .|::.:..||:|.::|..:|.|.:|:|.||:.|.:|||.|||:|||.||||
Mouse   586 NRCLADGREPGGP-SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTAN 649

  Fly   757 LAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSV 821
            ||||||..|...:.|||:|.:...|....|.|:|||:|...|:..|...:..||.||.::|:..|
Mouse   650 LAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGV 714

  Fly   822 ADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKR 884
            .|.:.::..|.||:||||..||:|:..:||.|:|:|:||.  :|.||||:|..::|.:.:..:..
Mouse   715 DDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLA 779

  Fly   885 LLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYF 949
            :|:...:|::|.|...|:||.|...|.|..||. |.::.....|.:|.|.:.|:.:..:.||:::
Mouse   780 ILQLFGDGEMEELEALWLTGICHNEKNEVMSSQ-LDIDNMAGVFYMLGAAMALSLITFICEHLFY 843

  Fly   950 KYIRKRLAKKDGGHC----CA-----LISLSMGKSLTFRGAVFEA----------------TEIL 989
            ...|         ||    |:     :.|:|.|......|...|.                :.||
Mouse   844 WQFR---------HCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNIL 899

  Fly   990 K-----------------------------------KHR-------C---NDPICDTHLWKVKHE 1009
            :                                   :||       |   |:|.|:.:|:.
Mouse   900 RLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS---- 960

  Fly  1010 LDMSRLRVRQLEKVMDKHGIKAPQLRLASSSDLLNHHHLKERPPLLGNLSLAASAQDLY 1068
             |.    :.::|:...       .|:|..|:...:|:|...||..:|:.|   |...||
Mouse   961 -DY----ISEVERTFG-------NLQLKDSNVYQDHYHHHHRPHSIGSTS---SIDGLY 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	94/382 (25%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	165/407 (41%)
		Lig_chan	665..928	CDD:278489	99/264 (38%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	93/377 (25%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	165/407 (41%)
		NMDAR2_C	840..1482	CDD:402274	33/193 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846453
Domainoid	1	1.000	214	1.000	Domainoid score	I2719
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1578
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000775
OrthoInspector	1	1.000	-	-		otm43044
orthoMCL	1	0.900	-	-		OOG6_102799
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3072
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.880