Protein Alignment Nmdar2 and Grik5

DIOPT Version :9

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_030098003.1
• Gene: Grik5 / 14809
• MGIID: 95818
• Length: 1003
• Species: Mus musculus
• Alignment Length: 1072
• Identity: 244/1072 - (22%)
• Similarity: 408/1072 - (38%)
• Gaps: 301/1072 - (28%)

  Fly    59 PISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYL----- 118
            |..||||.::...   ..|||.|      .||...|          ::...|..|:.|.|
Mouse     2 PAELLLLLIVAFA---NPSCQVL------SSLRMAA----------ILDDQTVCGRGERLALALA 47

  Fly   119 -RSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSL-TPSPTAILSTLCKEFLRVNVSAILY 181
             ..||..:....|.|                :..|:..| ..|......|:| :.|...|.::|.
Mouse    48 REQINGIIEVPAKAR----------------VEVDIFELQRDSQYETTDTMC-QILPKGVVSVLG 95

  Fly   182 MMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQ--------LAPSIEH 238
            ..:      |.|||.....:.|...||.|          :...:.|.:||        |.||.|.
Mouse    96 PSS------SPASASTVSHICGEKEIPHI----------KVGPEETPRLQYLRFASVSLYPSNED 144

  Fly   239 QSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFK-FTILNSIVVTRTSD---- 298
            .|.|:..||:.:.:...|::.           |..|.:..::|..: |.|....:..|..|
Mouse   145 VSLAVSRILKSFNYPSASLIC-----------AKAECLLRLEELVRGFLISKETLSVRMLDDSRD 198

  Fly   299 ----LMELVNSEARVMLLYATQTEAITILR-----------------------AAEEMKLTGENY 336
                |.|:.:.:...:::.|..:.:..:||                       .|.|:.:|...|
Mouse   199 PTPLLKEIRDDKVSTIIIDANASISHLVLRLSLNLSSPLGFPRSLPLGLSCVLQASELGMTSAFY 263

  Fly   337 VWVVSQSVIEKKDAHSQFPV-----------GMLGVH-FDTS----------------------- 366
            .::::.         ..||:           .:||.. |:||
Mouse   264 KYILTT---------MDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEAST 319

  Fly   367 ------SAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLR 425
                  |||||   .:|:.:....|.     ..||.:.:..:.|:|  .....|.:|.....|||
Mouse   320 YPGPALSAALM---FDAVHVVVSAVR-----ELNRSQEIGVKPLAC--TSANIWPHGTSLMNYLR 374

  Fly   426 NVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWET-----QKLDIRD 485
            .|..:|...:  :||.:.|...:..|:|:......:      .|||||.|..|     ..|||.
Mouse   375 MVEYDGLTGR--VEFNSKGQRTNYTLRILEKSRQGH------REIGVWYSNRTLAMNATTLDIN- 430

  Fly   486 IAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSP-ADPVSGKCLMDRGVLCRVAADHEMAADID 549
                     ..|.:..| .|.:|.:.|.||:...| ...:||
Mouse   431 ---------LSQTLANK-TLVVTTILENPYVMRRPNFQALSG----------------------- 462

  Fly   550 VGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLE-NGKWNGLIADLVNR-KT 612
                  ||.|    .|||:|:|.:.||.|.|.|.|..||||.:|..| ||.|.|::.:|:|| |.
Mouse   463 ------NERF----EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKA 517

  Fly   613 DMVLTSLMINTEREAVVDFSEPFMETGIAIV----VAKRTGIISPTAFLEPFDTASWMLVGIVAI 673
            |:.:.:..|..|||.|:|||:|||..||:|:    :.::.|..|   ||:||..|.|:.: ::|.
Mouse   518 DLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPAVWLFM-LLAY 578

  Fly   674 QAATFMIFL------FEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRG 732
            .|.:.::||      :||.:|.    .......::...:::|..:.|.......|....: .||.
Mouse   579 LAVSCVLFLAARLSPYEWYNPH----PCLRARPHILENQYTLGNSLWFPVGGFMQQGSEI-MPRA 638

  Fly   733 FTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSH 797
            .::|.::.||..|.::.::.||||||||:..:.........:|      .:.:.:.::|||   |
Mouse   639 LSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADD------LADQTNIEYGTI---H 694

  Fly   798 TDSTI-------HKYFNVMHNYMRQYNKT----SVADGVAAVLNGNLDSFIYDGTVLDYLVAQDE 851
            ..||:       ::.:..|.|||:....:    |..:|:|.|||... :|:.:.|:.:|  .:..
Mouse   695 AGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY-AFLLESTMNEY--HRRL 756

  Fly   852 DCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSS 916
            :|.|..:|......|||:.....|.:.......:|:.:.|..||.|:|.|..|...|.:::|::.
Mouse   757 NCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAK 821

  Fly   917 DPLALEQFLSAFLLLMAGILLAALLLLLEHVYF---------------------------KYIRK 954
            . |.:|.....|::|:.|:::|..:.::|.::.                           |..|.
Mouse   822 G-LGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRS 885

  Fly   955 RLAKKDGGHCCALISLSMGKSLTF-RGAVFEA 985
            |..::.||...||:||...:.:.. .|.::.|
Mouse   886 RRRRRPGGPSRALLSLRAVREMRLSNGKLYSA 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	92/483 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	119/429 (28%)
		Lig_chan	665..928	CDD:278489	64/279 (23%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	92/481 (19%)
		Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	118/425 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846661
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740