DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and Grik3

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001074566.1	Gene:	Grik3 / 14807	MGIID:	95816	Length:	919	Species:	Mus musculus

Alignment Length:	940	Identity:	210/940 - (22%)
Similarity:	382/940 - (40%)	Gaps:	179/940 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 SFEQKNIHF-DMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQ-LAGYL 205
            :::.:.||| |....|       ...|.: |.:.|.||        ||.|..|....:| :...|
Mouse    80 TYDIQRIHFHDSFEAT-------KKACDQ-LALGVVAI--------FGPSQGSCTNAVQSICNAL 128

  Fly   206 GIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQ 270
            .:|.|.....:..|:   ::.|..:.|.|.....|.|:|.:::..||...:||      :||...
Mouse   129 EVPHIQLRWKHHPLD---NKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVV------YDDSTG 184

  Fly   271 AVRER---VAEMQEHFKFTILNSIVVTRTSD--LMELVNSEARVMLLYATQTEAITILRAAEEMK 330
            .:|.:   :|..:.:.:..|....:.:..|.  |.|:.......::...:.|.|..||:.|..|.
Mouse   185 LIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMG 249

  Fly   331 LTGENYVW-------------------------------------VVSQSVIEKKDAHSQFPVGM 358
            :..|.|.:                                     :|.:..:|:..|..:...|:
Mouse   250 MMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWAMERLQAAPRAESGL 314

  Fly   359 L-GVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFK 422
            | ||..  :.|||:.:..:.:.:      .|...|     ::|..||.|  .....|..|..|..
Mouse   315 LDGVMM--TDAALLYDAVHIVSV------CYQRAP-----QMTVNSLQC--HRHKAWRFGGRFMN 364

  Fly   423 YLRNVSIEGDLNKPNIEFTADGDLRS-AELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDI 486
            :::....||...:  |.|.....||: .:|.|::|:...      .|::|||.  ....|:|.::
Mouse   365 FIKEAQWEGLTGR--IVFNKTSGLRTDFDLDIISLKEDG------LEKVGVWS--PADGLNITEV 419

  Fly   487 AWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVG 551
            | .|........:..:..:..|.||| |::....:|..
Mouse   420 A-KGRGPNVTDSLTNRSLIVTTVLEE-PFVMFRKSDRT--------------------------- 455

  Fly   552 QAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLEN-GKWNGLIADLVNRKTDMV 615
             .:.|:.|    .|:|||||::.|..|||:||:..|||||:|..:: |:|||::.:|::.|.|:.
Mouse   456 -LYGNDRF----EGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLA 515

  Fly   616 LTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPT--AFLEPFDTASWM--LVGIVAIQAA 676
            :..|.|...||..:|||:|||..|::|:..|..| .:|:  :||.|.....||  |:..:.:...
Mouse   516 VAPLTITHVREKAIDFSKPFMTLGVSILYRKPNG-TNPSVFSFLNPLSPDIWMYVLLAYLGVSCV 579

  Fly   677 TFMIFLF---EWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFM 738
            .|:|..|   ||     ||.......:.|....|:|..::|.....|.|....: .|:..::|.:
Mouse   580 LFVIARFSPYEW-----YDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSEL-MPKALSTRII 638

  Fly   739 TNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHT----- 798
            ..:|..|.::.::.||||||||:............:|      .:.:...::|.:....|
Mouse   639 GGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD------LAKQTKIEYGAVKDGATMTFFK 697

  Fly   799 ---DSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGS 860
               .||..|.:..|.:......|.: .:|:...|..:. :.:.:.|.::|:.  ..:|.|..:|.
Mouse   698 KSKISTFEKMWAFMSSKPSALVKNN-EEGIQRTLTADY-ALLMESTTIEYIT--QRNCNLTQIGG 758

  Fly   861 WYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFL 925
            .....|||:.....|.|.......:|:.:....|..::..|..|:..| ::|:|.:..|.:::..
Mouse   759 LIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCP-EEENKEASALGIQKIG 822

  Fly   926 SAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMGKSLTFRGAVFEATEILK 990
            ..|::|.||::|:.|:.:.|.:|  .:|| .|:::....|:.::..:..|||.:..:
Mouse   823 GIFIVLAAGLVLSVLVAVGEFIY--KLRK-TAEREQRSFCSTVADEIRFSLTCQRRL-------- 876

  Fly   991 KHRCNDPICDTHLWKVKHELDMSRLRVRQL 1020
            ||:...|:    :.|....::|.....|:|
Mouse   877 KHKPQPPM----MVKTDAVINMHTFNDRRL 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	80/392 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	103/421 (24%)
		Lig_chan	665..928	CDD:278489	56/275 (20%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	78/386 (20%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	102/417 (24%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846656
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740