Protein Alignment Nmdar2 and Grik2

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_011241422.1
• Gene: Grik2 / 14806
• MGIID: 95815
• Length: 943
• Species: Mus musculus
• Alignment Length: 994
• Identity: 225/994 - (22%)
• Similarity: 386/994 - (38%)
• Gaps: 236/994 - (23%)

  Fly   118 LRSINNAVTGLTKTRGAKLTF------LKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNV 176
            :.:||...|.|..|   .||:      |.| |||......|.:||                  .|
Mouse    61 VNTINRNRTLLPNT---TLTYDTQKINLYD-SFEASKKACDQLSL------------------GV 103

  Fly   177 SAILYMMNNEQFGHS-TASAQYFLQLAGYLGIPVIS--WN---ADNSGLERRASQSTLQLQLAPS 235
            :||        ||.| ::||.....:...||:|.|.  |.   :||        :.:..:.|.|.
Mouse   104 AAI--------FGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDN--------KDSFYVSLYPD 152

  Fly   236 IEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVR-ERVAEMQEHFKFTILNSIVVTRTSD- 298
            ....|.|:|.:::.:||...:||      :||....:| :.:.:....:...:....:...|.|
Mouse   153 FSSLSRAILDLVQFFKWKTVTVV------YDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDA 211

  Fly   299 ---LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVS------------------- 341
               |.|:...:...::...:...|..||:.|..|.:..|.|.::.:
Mouse   212 KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNM 276

  Fly   342 -------------QSVIEKKDAHS-QFP----VGMLGVHFDTSSAALMNEISNAIKIYSYGVEAY 388
                         .|:|||..... |.|    .|:|. .|.|:.||||.:   |:.:.|..|:.:
Mouse   277 TGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD-GFMTTDAALMYD---AVHVVSVAVQQF 337

  Fly   389 LTDPANRDRRLTTQSLSCEDEGRGR-WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRS-AEL 451
                    .::|..||.|   .|.: |..|..|...::....||...:  |.|.....||: .:|
Mouse   338 --------PQMTVSSLQC---NRHKPWRFGTRFMSLIKEAHWEGLTGR--ITFNKTNGLRTDFDL 389

  Fly   452 KIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKF---HLKITFLEEA 513
            .:::|:.....|...|:........|:||             ..|..:.:..   .|.:|.:.|.
Mouse   390 DVISLKEEGLEKIGTWDPSSGLNMTESQK-------------GKPANITDSLSNRSLIVTTILEE 441

  Fly   514 PYINLSPAD-PVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEE 577
            ||:....:| |:.|                             |:.|    .|:|||||.:.:..
Mouse   442 PYVLFKKSDKPLYG-----------------------------NDRF----EGYCIDLLRELSTI 473

  Fly   578 LGFTYELVRVEDGKWGTLE--NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGI 640
            ||||||:..|||||:|..:  ||:|||::.:|::.|.|:.:..|.|...||.|:|||:|||..||
Mouse   474 LGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGI 538

  Fly   641 AIVVAKRTGIISP--TAFLEPFDTASWM--LVGIVAIQAATFMI---FLFEWL---SPSGY---- 691
            :|:..|..| .:|  .:||.|.....||  |:..:.:....|:|   ..|.|.   :.|.|
Mouse   539 SILYRKPNG-TNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARQSKFSWFKYPNCSHYHHSQ 602

  Fly   692 ------DMKLYLQNTNVTPY-----------------RFSLFRTYWLVWAVLFQAAVHVDSPRGF 733
                  .::.|::....:||                 .|:|..::|.....|.|....: .|:..
Mouse   603 RCLCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSEL-MPKAL 666

  Fly   734 TSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHT 798
            ::|.:..:|..|.::.::.||||||||:............:|      .:.:...::|.:....|
Mouse   667 STRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD------LAKQTKIEYGAVEDGAT 725

  Fly   799 --------DSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRL 855
                    .||..|.:..|.:..:.....|..:|:..||..:. :|:.:.|.::::.  ..:|.|
Mouse   726 MTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-AFLMESTTIEFVT--QRNCNL 787

  Fly   856 MTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLA 920
            ..:|......|||:.....|.|.......:|:.:..|.|..::..|..|...| ::|.|.:..|.
Mouse   788 TQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP-EEESKEASALG 851

  Fly   921 LEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALI-----SLSMGKSLTFR- 979
            ::.....|::|.||::|:..:.:.|.:|......:|.|:  ..|.|::     ||...:.|..:
Mouse   852 VQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKR--SFCSAMVEELRMSLKCQRRLKHKP 914

  Fly   980 --GAVFEATEILKKHRCND 996
              ..:.:..|::..|..||
Mouse   915 QAPVIVKTEEVINMHTFND 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	91/422 (22%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	111/456 (24%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	88/413 (21%)
		Periplasmic_Binding_Protein_Type_2	430..835	CDD:473866	110/448 (25%)