DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and Grik2

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	994	Identity:	225/994 - (22%)
Similarity:	386/994 - (38%)	Gaps:	236/994 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LRSINNAVTGLTKTRGAKLTF------LKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNV 176
            :.:||...|.|..|   .||:      |.| |||......|.:||                  .|
Mouse    61 VNTINRNRTLLPNT---TLTYDTQKINLYD-SFEASKKACDQLSL------------------GV 103

  Fly   177 SAILYMMNNEQFGHS-TASAQYFLQLAGYLGIPVIS--WN---ADNSGLERRASQSTLQLQLAPS 235
            :||        ||.| ::||.....:...||:|.|.  |.   :||        :.:..:.|.|.
Mouse   104 AAI--------FGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDN--------KDSFYVSLYPD 152

  Fly   236 IEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVR-ERVAEMQEHFKFTILNSIVVTRTSD- 298
            ....|.|:|.:::.:||...:||      :||....:| :.:.:....:...:....:...|.|
Mouse   153 FSSLSRAILDLVQFFKWKTVTVV------YDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDA 211

  Fly   299 ---LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVS------------------- 341
               |.|:...:...::...:...|..||:.|..|.:..|.|.::.:
Mouse   212 KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNM 276

  Fly   342 -------------QSVIEKKDAHS-QFP----VGMLGVHFDTSSAALMNEISNAIKIYSYGVEAY 388
                         .|:|||..... |.|    .|:|. .|.|:.||||.:   |:.:.|..|:.:
Mouse   277 TGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD-GFMTTDAALMYD---AVHVVSVAVQQF 337

  Fly   389 LTDPANRDRRLTTQSLSCEDEGRGR-WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRS-AEL 451
                    .::|..||.|   .|.: |..|..|...::....||...:  |.|.....||: .:|
Mouse   338 --------PQMTVSSLQC---NRHKPWRFGTRFMSLIKEAHWEGLTGR--ITFNKTNGLRTDFDL 389

  Fly   452 KIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKF---HLKITFLEEA 513
            .:::|:.....|...|:........|:||             ..|..:.:..   .|.:|.:.|.
Mouse   390 DVISLKEEGLEKIGTWDPSSGLNMTESQK-------------GKPANITDSLSNRSLIVTTILEE 441

  Fly   514 PYINLSPAD-PVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEE 577
            ||:....:| |:.|                             |:.|    .|:|||||.:.:..
Mouse   442 PYVLFKKSDKPLYG-----------------------------NDRF----EGYCIDLLRELSTI 473

  Fly   578 LGFTYELVRVEDGKWGTLE--NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGI 640
            ||||||:..|||||:|..:  ||:|||::.:|::.|.|:.:..|.|...||.|:|||:|||..||
Mouse   474 LGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGI 538

  Fly   641 AIVVAKRTGIISP--TAFLEPFDTASWM--LVGIVAIQAATFMI---FLFEWL---SPSGY---- 691
            :|:..|..| .:|  .:||.|.....||  |:..:.:....|:|   ..|.|.   :.|.|
Mouse   539 SILYRKPNG-TNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARQSKFSWFKYPNCSHYHHSQ 602

  Fly   692 ------DMKLYLQNTNVTPY-----------------RFSLFRTYWLVWAVLFQAAVHVDSPRGF 733
                  .::.|::....:||                 .|:|..::|.....|.|....: .|:..
Mouse   603 RCLCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSEL-MPKAL 666

  Fly   734 TSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHT 798
            ::|.:..:|..|.::.::.||||||||:............:|      .:.:...::|.:....|
Mouse   667 STRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD------LAKQTKIEYGAVEDGAT 725

  Fly   799 --------DSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRL 855
                    .||..|.:..|.:..:.....|..:|:..||..:. :|:.:.|.::::.  ..:|.|
Mouse   726 MTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-AFLMESTTIEFVT--QRNCNL 787

  Fly   856 MTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLA 920
            ..:|......|||:.....|.|.......:|:.:..|.|..::..|..|...| ::|.|.:..|.
Mouse   788 TQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCP-EEESKEASALG 851

  Fly   921 LEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALI-----SLSMGKSLTFR- 979
            ::.....|::|.||::|:..:.:.|.:|......:|.|:  ..|.|::     ||...:.|..:
Mouse   852 VQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKR--SFCSAMVEELRMSLKCQRRLKHKP 914

  Fly   980 --GAVFEATEILKKHRCND 996
              ..:.:..|::..|..||
Mouse   915 QAPVIVKTEEVINMHTFND 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	91/427 (21%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	111/456 (24%)
		Lig_chan	665..928	CDD:278489	59/305 (19%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	88/413 (21%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	110/448 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840