DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and Grik1

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	1035	Identity:	239/1035 - (23%)
Similarity:	406/1035 - (39%)	Gaps:	242/1035 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 TVLTLL-----ILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAV 125
            |..|||     ||...|.|.||:   ||...   ....|.:|:..:|             ...||
Mouse    17 TSWTLLYFLCYILPQTSPQVLRI---GGIFE---TVENEPVNVEELA-------------FKFAV 62

  Fly   126 TGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGH 190
            |.:.:.|.........|..::.|: ||  |...|..|     |.: |.:.|:|:        ||.
Mouse    63 TSINRNRTLMPNTTLTYDIQRINL-FD--SFEASRRA-----CDQ-LALGVAAL--------FGP 110

  Fly   191 STASAQYFLQ-LAGYLGIPVIS--W---NADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILER 249
            |.:|:...:| :...|.:|.|.  |   :.||..|        ..:.|.|.....|.|:|.::..
Mouse   111 SHSSSVSAVQSICNALEVPHIQTRWKHPSVDNRDL--------FYINLYPDYAAISRAVLDLVLY 167

  Fly   250 YKWHQFSVVTSQIAGHDDFVQAVR-ERVAEMQEHFKFTILNSIVVTRTSD----LMELVNSEARV 309
            |.|...:||      ::|....:| :.:.:....:...|....:.:...|    |.|:...:...
Mouse   168 YNWKTVTVV------YEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFY 226

  Fly   310 MLLYATQTEAITILRAAEEMKLTGENYVWVVS--------------------------------Q 342
            ::...:...|..||:....|.:..|.|.:..:                                .
Mouse   227 VIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVS 291

  Fly   343 SVIEKKDAHS-QFP----VGML-GVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTT 401
            |:|||..... |.|    .|:| ||.  |:.||||.:....:.|.|:           |..:||.
Mouse   292 SIIEKWSMERLQAPPRPETGLLDGVM--TTEAALMYDAVYMVAIASH-----------RASQLTV 343

  Fly   402 QSLSCEDEGRGR-WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSAN---- 461
            .||.|.   |.: |..|..|...::....:|...:.....| ||..:..:|.|::|:....
Mouse   344 SSLQCH---RHKPWRLGPRFMNLIKEARWDGLTGRITFNKT-DGLRKDFDLDIISLKEEGTEKAS 404

  Fly   462 ---NKNL--VWEEIGVWKSWETQKLDIRDIAWPGN---SHAPPQGVPEKFHLKITFLEEAPYINL 518
               :|:|  ||::||:|.|  ...|::.|    ||   |:.....:..:..:..|.||| ||:..
Mouse   405 GEVSKHLYKVWKKIGIWNS--NSGLNMTD----GNRDRSNNITDSLANRTLIVTTILEE-PYVMY 462

  Fly   519 SPAD-PVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTY 582
            ..:| |:.|                             |:.|    .|:|:|||::.:..|||.|
Mouse   463 RKSDKPLYG-----------------------------NDRF----EGYCLDLLKELSNILGFLY 494

  Fly   583 ELVRVEDGKWGTL-ENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK 646
            ::..|.|||:|.. :.|:|||::.:|::.:.|:.:..|.|...||.|:|||:|||..||:|:..|
Mouse   495 DVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK 559

  Fly   647 RTGIISP--TAFLEPFDTASWM--LVGIVAIQAATFMIFLF---EWLSPSGYDMKLYLQNTNVTP 704
            ..| .:|  .:||.|.....||  |:..:.:....|:|..|   ||.:|...:     .:::|..
Mouse   560 PNG-TNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCN-----PDSDVVE 618

  Fly   705 YRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFM-------- 761
            ..|:|..::|.....|.|....: .|:..::|.:..:|..|.::.::.||||||||:
Mouse   619 NNFTLLNSFWFGVGALMQQGSEL-MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESP 682

  Fly   762 ------ITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTS 820
                  :.::...|:..:.|.      |....||...|      ||..|.:..|.:..:.....:
Mouse   683 IDSADDLAKQTKIEYGAVRDG------STMTFFKKSKI------STYEKMWAFMSSRQQSALVKN 735

  Fly   821 VADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRL 885
            ..:|:..||..:. :.:.:.|.::|:.  ..:|.|..:|......|||:.....|.|.......:
Mouse   736 SDEGIQRVLTTDY-ALLMESTSIEYVT--QRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 797

  Fly   886 LEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFK 950
            |:.:..|.|..::..|..|...| :::.|.:..|.:|.....|::|.||::|:..:.:.|.:|..
Mouse   798 LQLQEEGKLHMMKEKWWRGNGCP-EEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKS 861

  Fly   951 -----------------YIRKRLAKKDGGHCCALISLSMGKSLTFRGAVFEATEILKKHR 993
                             |.|.::.    .|.....||.:.|.|:| .|:.|...|..|::
Mouse   862 RKNNDIEQKGKSSRLRFYFRNKVR----FHGSKTESLGVEKCLSF-NAIMEELGISLKNQ 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	95/449 (21%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	106/428 (25%)
		Lig_chan	665..928	CDD:278489	59/281 (21%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	97/461 (21%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	105/424 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740