Protein Alignment Nmdar2 and Grid2

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_032193.1
• Gene: Grid2 / 14804
• MGIID: 95813
• Length: 1007
• Species: Mus musculus
• Alignment Length: 921
• Identity: 219/921 - (23%)
• Similarity: 371/921 - (40%)
• Gaps: 210/921 - (22%)

  Fly   135 KLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG--HSTASAQY 197
            |:||  ..:|...|          :|...:...| |.:...:.|::..:.....|  .|.|.|.:
Mouse    62 KITF--SVTFVDGN----------NPFQAVQEAC-ELMNQGILALVSSIGCTSAGSLQSLADAMH 113

  Fly   198 ----FLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVV 258
                |:| ....|.|     ....||.|........|.:.|.: :.:..:|.::..|.|.:|.:.
Mouse   114 IPHLFIQ-RSTAGTP-----RSGCGLTRSNRNDDYTLSVRPPV-YLNEVILRVVTEYAWQKFIIF 171

  Fly   259 TS---QIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVT-----RTSDLMELVNSEARVMLLYAT 315
            ..   .|.|..:|:..|.::..::........:|.::.|     |..:|....::..|.:|:...
Mouse   172 YDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNP 236

  Fly   316 QTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDA--------------HSQFPVG-------ML 359
            .| |.:.:....|..|...:..|::....|...|.              ...|||.       ..
Mouse   237 AT-AKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFR 300

  Fly   360 GVHFDTSSA-------ALMNEISNAIKIYSYGVEAYLTDPANR---DRRL-TTQSLSCEDEGRGR 413
            |.|..:||.       |...||||   :|.|.....|.:..::   ||:. :..||||..:....
Mouse   301 GNHRISSSLCDPKDPFAQNMEISN---LYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKP 362

  Fly   414 WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWET 478
            |..|....:.::...:.|          ..|||...|        :..|.|:.:|.:|.....|.
Mouse   363 WQGGRSMLETIKKGGVNG----------LTGDLEFGE--------NGGNPNVHFEILGTNYGEEL 409

  Fly   479 QKLDIRDI-AWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSG--KCLMD-------RG 533
            .: .:|.: .|                                 :||:|  ..|.|       ||
Mouse   410 GR-GVRKLGCW---------------------------------NPVTGLNGSLTDKKLENNMRG 440

  Fly   534 VLCRVAADHE----MAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGT 594
            |:.||....|    |.::..:|:..:    ||   ||.||:|:..:..|||.||:....|.|:|:
Mouse   441 VVLRVVTVLEEPFVMVSENVLGKPKK----YQ---GFSIDVLDALSNYLGFNYEIYVAPDHKYGS 498

  Fly   595 -LENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLE 658
             .|:|.||||:.:||.::.|:.:::|.|..:||.||||:..:|:..:.:::.:....:...|.|.
Mouse   499 PQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLA 563

  Fly   659 PFDTASW-------MLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLV 716
            |||.:.|       :|||:        :::|..||:|....|......|        |:.:.|.|
Mouse   564 PFDLSLWACIAGTVLLVGL--------LVYLLNWLNPPRLQMGSMTSTT--------LYNSMWFV 612

  Fly   717 WAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFM-ITREEFHEFSGLNDSRLVH 780
            :....|....|.... ..:|.|...|.|||::.::.||||||||: |||.| .....|.|
Mouse   613 YGSFVQQGGEVPYTT-LATRMMMGAWWLFALIVISSYTANLAAFLTITRIE-SSIQSLQD----- 670

  Fly   781 PFSHKPSFKFGTIPYSHTDSTIHKYFNV----------MHNYM-RQYNKTSVAD--------GVA 826
             .|.:....:||:    .||.::::..:          |::.| |..|:::.::        |:.
Mouse   671 -LSKQTDIPYGTV----LDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQ 730

  Fly   827 AVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRAN 891
            .|..||. :|::|..||:|:...|.||...|||:..|..|||:|....|.|..:|::|:||.:.:
Mouse   731 KVKYGNY-AFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQS 794

  Fly   892 GDLERLRRYW--MTGTCR-----PGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYF 949
            ||::.|:..|  ..|.|.     ..||:..:.|   ::.....|.:|.|||:|:.|:.:||..:.
Mouse   795 GDMDILKHKWWPKNGQCDLYSSVDAKQKGGALD---IKSLAGVFCILAAGIVLSCLIAVLETWWS 856

  Fly   950 KYIRKRLAKKD 960
            :....|:..|:
Mouse   857 RRKGSRVPSKE 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	76/395 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	127/453 (28%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		58/306 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	81/442 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	119/401 (30%)
		Interaction with AP4M1. /evidence=ECO:0000250|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007