DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and Grid1

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	843	Identity:	211/843 - (25%)
Similarity:	342/843 - (40%)	Gaps:	177/843 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 ASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAA----------MLSIL 247
            |||.....|...:.||.:....:..|..|.|    ..|..:|..|..:.|          ||.::
Mouse    97 ASANALQSLTDAMHIPHLFVQRNPGGSPRTA----CHLNPSPDGEAYTLASRPPVRLNDVMLRLV 157

  Fly   248 ERYKWHQFSVVTS---QIAGHDDFV-QAVR-------ERVAEMQEHFKFTILNSIVVT-RTSDLM 300
            ...:|.:|.:...   .|.|...|: ||.|       ::|.:...|    :..|:..| :|.:|.
Mouse   158 TELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISH----VFTSLFTTMKTEELN 218

  Fly   301 ELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKD----AHSQ-------- 353
            ...::..|.:||.:.| .|.:.:..|.|..|..::..||.....|...:    .||.
Mouse   219 RYRDTLRRAILLLSPQ-GAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVR 282

  Fly   354 --FPVG------MLGVH------FDTSSAAL-MNEISNAIKIYSYGVEAYLTDPANR---DRRL- 399
              ||..      |...|      .|.....| |.:|||   :|.|.....|.:..:|   ||:.
Mouse   283 QIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISN---LYLYDSVLMLANAFHRKLEDRKWH 344

  Fly   400 TTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKN 464
            :..||:|..:....|:.|......::...|.|        .|.          :|..|..::|..
Mouse   345 SMASLNCIRKSTKPWNGGRSMLDTIKKGHITG--------LTG----------VMEFREDSSNPY 391

  Fly   465 LVWEEIGVWKSWETQKLDIRDIA-WP------GNSHAPPQGVP-EKFHLKITFLEEAPYINLSPA 521
            :.:|.:|...| ||...|:|.:| |.      |:....|.|.. :...||:..:.|.|::
Mouse   392 VQFEILGTTYS-ETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFV----- 450

  Fly   522 DPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVR 586
                                  |.|:..:||..|.:       ||.||:|:..|:.|||.||:.:
Mouse   451 ----------------------MVAENILGQPKRYK-------GFSIDVLDALAKALGFKYEIYQ 486

  Fly   587 VEDGKWG-TLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGI 650
            ..||::| .|.|..|||:|.:|::::.|:.::::.|..|||:|||||:.:|:..:.|::.|....
Mouse   487 APDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEK 551

  Fly   651 ISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFS----LFR 711
            ||..:...|||.|.|..:. .||.....:||:...:..        :::.:.|..|.|    |..
Mouse   552 ISIFSLFAPFDFAVWACIA-AAIPVVGVLIFVLNRIQA--------VRSQSATQPRPSASATLHS 607

  Fly   712 TYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFM-ITREEFHEFSGLND 775
            ..|:|:....|.... .|......|.:...|.||.::..:.||||||||: ::|.:       |.
Mouse   608 AIWIVYGAFVQQGGE-SSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMD-------NP 664

  Fly   776 SRLVHPFSHKPSFKFGTIPYSHTDSTIHKYF-----------NVMHNYMRQYNKTSVAD------ 823
            .|.....|.:....:||:    .||.:::||           :......|..:|...||
Mouse   665 IRTFQDLSKQLEMSYGTV----RDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNP 725

  Fly   824 --GVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLL 886
              |:.....||. :|::|..|::|....|:||.:..:|:..:..|||:|....|.|..:|::|:|
Mouse   726 SEGIRKAKKGNY-AFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRIL 789

  Fly   887 EFRANGDLERLRRYWMTGTCRPGKQEHKSSD----PLALEQFLSAFLLLMAGILLAALLLLLE 945
            |.:..|||:.|::.|...|.|.....|.|:.    .|.|..|...|.:|..|:|||.|:..||
Mouse   790 ELQDTGDLDVLKQKWWPHTGRCDLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAALE 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	78/356 (22%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	115/430 (27%)
		Lig_chan	665..928	CDD:278489	72/290 (25%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		81/369 (22%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	78/356 (22%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	114/425 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740