DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and Gria4

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	1011	Identity:	235/1011 - (23%)
Similarity:	398/1011 - (39%)	Gaps:	219/1011 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 LTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKTRGAKLTFLKDYSFEQK 147
            |.:|...|:.||..:..|:. ||...:|:   :||           |..|.|  .||.:.|....
Mouse    11 LFSGFWGLAMGAFPSSVQIG-GLFIRNTD---QEY-----------TAFRLA--IFLHNTSPNAS 58

  Fly   148 NIHFDMMS-----LTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG-HSTASAQYFLQLAGYLG 206
            ...|:::.     .|.:..|:.:..|.::.| .|.||        || :...|..........|.
Mouse    59 EAPFNLVPHVDNIETANSFAVTNAFCSQYSR-GVFAI--------FGLYDKRSVHTLTSFCSALH 114

  Fly   207 IPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQA 271
            |.:|:.:....|      :|...|||.||:.   .|:||:|:.|:|:.|..:.....|: ..:||
Mouse   115 ISLITPSFPTEG------ESQFVLQLRPSLR---GALLSLLDHYEWNCFVFLYDTDRGY-SILQA 169

  Fly   272 VRERVAEMQEHFKFTILNSIVVTRTSD------LMELVNSEARVMLLYATQTEAITILRAAEEMK 330
            :.|:..:...|     :::|.|...:|      |.||   :.|....:....|...:....|::.
Mouse   170 IMEKAGQNGWH-----VSAICVENFNDVSYRQLLEEL---DRRQEKKFVIDCEIERLQNILEQIV 226

  Fly   331 LTGEN---YVWVVS----QSVIEKKDAHSQFPV-GMLGVHFDTSSAALMNEISNAIKIYSY-GVE 386
            ..|::   |.::::    :.:..::..|....| |...|.|:|.....:.:....:....| |.|
Mouse   227 SVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPGSE 291

  Fly   387 AYLTDP--------------ANRDRRLTTQSLSCEDEGR---------GRWDNGEIFFKYLRNVS 428
               |.|              |...|.|..|.:.....|.         ..|..|....:.|:.|.
Mouse   292 ---TPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVR 353

  Fly   429 IEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSH 493
            |:|...  |::|...|...:..:.:..|:.:...|      :|.|...:...| |:|....||..
Mouse   354 IQGLTG--NVQFDHYGRRVNYTMDVFELKSTGPRK------VGYWNDMDKLVL-IQDAPTLGNDT 409

  Fly   494 APPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNES 558
            |    ..|...:.:|.:.|:||:                    ....:|||        ...|:.
Mouse   410 A----AIENRTVVVTTIMESPYV--------------------MYKKNHEM--------FEGNDK 442

  Fly   559 FYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGT--LENGKWNGLIADLVNRKTDMVLTSLMI 621
            :    .|:|:||..:.|:.:|..|::..|.|||:|.  .:...|||::.:||..|.::.:..|.|
Mouse   443 Y----EGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTI 503

  Fly   622 NTEREAVVDFSEPFMETGIAIVVAK----RTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFL 682
            ...||.|:|||:|||..||:|::.|    :.|:.|   ||:|.....||.: :.|....:.::||
Mouse   504 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS---FLDPLAYEIWMCI-VFAYIGVSVVLFL 564

  Fly   683 ------FEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNV 741
                  :||.:....|.|  ...::..|..|.:|.:.|.......|....: |||..:.|.:..|
Mouse   565 VSRFSPYEWHTEEPEDGK--EGPSDQPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGV 626

  Fly   742 WALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHP------FSHKPSFKFGTIPYSHTDS 800
            |..|.::.::.||||||||            |...|:|.|      .:.:....:||:....|..
Mouse   627 WWFFTLIIISSYTANLAAF------------LTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKE 679

  Fly   801 TIHK----YFNVMHNYMRQ-----YNKTSVADGVAAV--LNGNLDSFIYDGTVLDYLVAQDEDCR 854
            ...:    .:..|..|||.     :.:|: |:|||.|  ..|.. :|:.:.|:.:| :.|.:.|.
Mouse   680 FFRRSKIAVYEKMWTYMRSAEPSVFTRTT-AEGVARVRKSKGKF-AFLLESTMNEY-IEQRKPCD 741

  Fly   855 LMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWM--TGTCRP---GKQEHK 914
            .|.||......|||:|..:.|......|..:|:....|.|::|:..|.  .|.|.|   |.::..
Mouse   742 TMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKT 806

  Fly   915 SSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMGKSL--- 976
            |:  |:|......|.:|:.|:.||.|:.|:|   |.|..:..||:          :.:.||.
Mouse   807 SA--LSLSNVAGVFYILVGGLGLAMLVALIE---FCYKSRAEAKR----------MKVAKSAQTF 856

  Fly   977 -------TFRGAVFEATEILKKHRCNDPICDTHLWK 1005
                   |...|.:...:..:.|:....:  .|.|:
Mouse   857 NPTSSQNTHNLATYREADFFRSHKKQSQV--IHHWE 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	88/434 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	114/436 (26%)
		Lig_chan	665..928	CDD:278489	73/290 (25%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	86/427 (20%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	113/434 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740