DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nmdar2 and GRIN3A

DIOPT Version :9

Sequence 1:NP_001014714.1 Gene:Nmdar2 / 31107 FlyBaseID:FBgn0053513 Length:1083 Species:Drosophila melanogaster
Sequence 2:NP_597702.2 Gene:GRIN3A / 116443 HGNCID:16767 Length:1115 Species:Homo sapiens


Alignment Length:850 Identity:241/850 - (28%)
Similarity:395/850 - (46%) Gaps:110/850 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 PTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLER--- 221
            |.:.|.::|...:...|||:|      .|..|.........::..|.|||||       :.|   
Human   177 PFSFLQSVCHTVVVQGVSALL------AFPQSQGEMMELDLVSLVLHIPVIS-------IVRHEF 228

  Fly   222 -RASQSTLQLQLA--PSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHF 283
             |.||:.|.|||:  .|:...:...:|||....|:.||::..|    :|:  .:.:.:...|.:.
Human   229 PRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQ----EDW--NITDFLLLTQNNS 287

  Fly   284 KFTILNSIVVT----RTSDL-------MELVNSEARVMLLYATQTEAI-TILRAAEEMKLTGENY 336
            ||.:.:.|.:|    .|.||       :|.:.:....::::....|:| .|.....:..:.....
Human   288 KFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPEL 352

  Fly   337 VWVV--SQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGV-EAYLTDPANRDRR 398
            .||:  ||:|.|.:.  ...|:|:: .|..|:.:...:.:.:|:::.:..| .|.:..|   :..
Human   353 RWVLGDSQNVEELRT--EGLPLGLI-AHGKTTQSVFEHYVQDAMELVARAVATATMIQP---ELA 411

  Fly   399 LTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLR-------SAE--LKIM 454
            |...:::|.:.......:|:...::|.|.:..|          ..|.:|       |:|  ..|.
Human   412 LIPSTMNCMEVETTNLTSGQYLSRFLANTTFRG----------LSGSIRVKGSTIVSSENNFFIW 466

  Fly   455 NLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWP--GNSHAPPQGVPEKFHLKITFLEEAPYIN 517
            ||:.....|.: |..:|   ||:..|:.:....||  ...|......|.|.||::..|.|.|::.
Human   467 NLQHDPMGKPM-WTRLG---SWQGGKIVMDYGIWP
EQAQRHKTHFQHPSKLHLRVVTLIEHPFVF 527

  Fly   518 LSPADPVSGKCLMDRGVLCRVAADHEMAA-DIDVGQAHRNE-----SFYQCCSGFCIDLLEKFAE 576
            ....|. .|.|  ..|.||.....::.:. |......|.:.     .|.:||.|:|||||||.||
Human   528 TREVDD-EGLC--PAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAE 589

  Fly   577 ELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIA 641
            ::.|.::|..|.|||:|..:||.|.||:.||:.....|.:||..|||.|..|:||:.||..|.:.
Human   590 DMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLG 654

  Fly   642 IVVAKRTGIISPTAFLEPFDTASWMLVGI-VAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPY 705
            |:|..|.......||:.|.....|:  || ||:......:.|:||.||.|           :||.
Human   655 ILVRTRDTAAPIGAFMWPLHWTMWL--GIFVALHITAVFLTLYEWKSPFG-----------LTPK 706

  Fly   706 R------FSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITR 764
            .      ||......:.:|:||...|.:..|:.:|.||:.|:||:|.:..|:.|||||||.|:..
Human   707 GRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGE 771

  Fly   765 EEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVL 829
            :.:.|.||::|.:|.||   ...|:|||:..|..:..:.:.|..||.|||:||..:..|||..:.
Human   772 KIYEELSGIHDPKLHHP---SQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLK 833

  Fly   830 NG--NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANG 892
            |.  .||:||.|..:|||.|:.|.||:|:|||..:|:.|||:....||......::.:.:::::|
Human   834 NDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHG 898

  Fly   893 DLERLRRYW-MTGTCRPGKQEHKSSDPL--ALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRK 954
            .::.|...| ....|  ||:....::.|  .::.|...|:||..|..|:.|..:.||:.::.:..
Human   899 FMDMLHDKWYRVVPC--GKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLP 961

  Fly   955 RLAKK 959
            |:..|
Human   962 RIKNK 966

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nmdar2NP_001014714.1 PBP1_iGluR_NMDA_NR2 99..490 CDD:107373 79/361 (22%)
PBP2_iGluR_NMDA_Nr2 502..908 CDD:270436 146/421 (35%)
Lig_chan 665..928 CDD:278489 90/274 (33%)
GRIN3ANP_597702.2 PBP1_iGluR_NMDA_NR3 30..497 CDD:107372 77/358 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..118
ANF_receptor 127..469 CDD:279440 70/326 (21%)
PBP2_iGluR_NMDA_Nr3 512..908 CDD:270438 144/414 (35%)
Lig_chan 676..942 CDD:278489 93/283 (33%)
PPP2CB binding site. /evidence=ECO:0000250 951..987 3/15 (20%)
GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7 1062..1095
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156095
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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