DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and Grik4

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	979	Identity:	228/979 - (23%)
Similarity:	403/979 - (41%)	Gaps:	241/979 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SGPISLL---LLTV--------LTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHT 110
            |.|:.||   ||.|        :..::.|...|            |:|     |:|:|.|..
Mouse     5 SAPLVLLPAWLLMVACSPHSLRIAAILDDPMEC------------SRG-----ERLSITLAK--- 49

  Fly   111 NFGKREYLRSINNAVTGLTKTRGAKLTF--LKDYSFEQKNIHFDMM----------SLTPSPTAI 163
                    ..||.|...|.|.:.....|  |:|..:|.......::          |.:|:.::|
Mouse    50 --------NRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSI 106

  Fly   164 LSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTL 228
            :|.:|.|               ::..|...:.:.|::..                |:|..:
Mouse   107 ISNICGE---------------KEVPHFKVAPEEFVRFQ----------------LQRFTT---- 136

  Fly   229 QLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFK-FTILNSIV 292
             |.|.||....|.|:..||     :.|:..|:.:      :.|..|.:..:::..: |.|....:
Mouse   137 -LNLHPSNTDISVAVAGIL-----NFFNCTTACL------ICAKAECLLNLEKLLRQFLISKDTL 189

  Fly   293 VTRTSD--------LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVS--QSVIEK 347
            ..|..|        |.|:.:.:...::::|..:.:.|||..|.|:.:....|.::.:  :..:::
Mouse   190 SVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQR 254

  Fly   348 KDAHSQFPVGMLGVHFDTSSAALMNEISNAIK--------------------IYSYGVEAYLT-- 390
            .|:.....|.:||......|.|...|.|.::.                    :....|.|.:|
Mouse   255 MDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAV 319

  Fly   391 DPANRDRRLTTQSLSCEDEGRGR-WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIM 454
            ...||.:.:..:.|||   |..: |.:|.....|||.|.:||...  :|||.:.|...:..|||:
Mouse   320 QELNRSQEIGVKPLSC---GSAQIWQHGTSLMNYLRMVELEGLTG--HIEFNSKGQRSNYALKIL 379

  Fly   455 NLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKFH---LKITFLEEAPYI 516
            ....:.      :::||.|...|...:|.|..|         ..:.:...   |.:|.:.|.||:
Mouse   380 QFTRNG------FQQIGQWHVAEGLSMDSRLYA---------SNISDSLFNTTLVVTTILENPYL 429

  Fly   517 NLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFT 581
            .|.                    .:|:        :...|:.:    .|||:|:|::.||.|.|.
Mouse   430 MLK--------------------GNHQ--------EMEGNDRY----EGFCVDMLKELAEILRFN 462

  Fly   582 YELVRVEDGKWGTLE-NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIV-- 643
            |::..|.||.:|..| ||.|.|::.:|:.||.|:.:..|.|..|||.|:|||:|||..||:|:
Mouse   463 YKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYR 527

  Fly   644 --VAKRTGIISPTAFLEPFDTASW--MLVGIVAIQAATFMIFL---FEWLSP----SGYDMKLYL 697
              :.:|.|..|   ||:||....|  ||:..:|:....|::..   :||.||    .|
Mouse   528 VHMGRRPGYFS---FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQG------- 582

  Fly   698 QNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMI 762
             ..|:...::||..:.|.......|....: :||..::|.::.||..|.::.::.||||||||:.
Mouse   583 -RCNLLVNQYSLGNSLWFPVGGFMQQGSTI-APRALSTRCVSGVWWAFTLIIISSYTANLAAFLT 645

  Fly   763 TREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTI-------HKYFNVMHNYMRQYNK-- 818
            .:........::|      .:.:.:.::|||   |..|::       ::.:..|.|||  |:|
Mouse   646 VQRMEVPIESVDD------LADQTAIEYGTI---HGGSSMTFFQNSRYQTYQRMWNYM--YSKQP 699

  Fly   819 ----TSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQ 879
                .|..:|:|.|||.|. :|:.:.|:.:|.  :..:|.|..:|......|||:.....|.:..
Mouse   700 SVFVKSTEEGIARVLNSNY-AFLLESTMNEYY--RQRNCNLTQIGGLLDTKGYGIGMPVGSVFRD 761

  Fly   880 MFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLL 944
            .|:..:|:.:.|..||.|:|.|..|...|.:::|::.. |.:|.....|::|:.|:::|..:.:|
Mouse   762 EFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKG-LGMENIGGIFVVLICGLIVAIFMAML 825

  Fly   945 EHVY 948
            |.::
Mouse   826 EFLW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	87/436 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	120/435 (28%)
		Lig_chan	665..928	CDD:278489	71/284 (25%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	88/463 (19%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	119/427 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740