DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and LOC110438919

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_021328141.1	Gene:	LOC110438919 / 110438919	-ID:	-	Length:	1417	Species:	Danio rerio

Alignment Length:	889	Identity:	283/889 - (31%)
Similarity:	454/889 - (51%)	Gaps:	91/889 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 QLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVA------EMQEHFKFTILN 289
            |..||||.|::.||:|:|.|.|:.||:||:...|:.|||..:|..:.      |::|   ..:|:
Zfish     4 QFGPSIEQQASVMLNIMEEYDWYIFSIVTTYYPGYQDFVTKIRSTIENSFVGWELEE---VLLLD 65

  Fly   290 SIVVTRTSDLMELVNS-EARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDAH-- 351
            ..|....:.:..|:.. ::.|:|||:|:.||..|.:.|..:.|||..|.|:|...|....| |
Zfish    66 MSVDDGDAKIQNLLKKLQSPVILLYSTKEEANIIFQVAHSVGLTGYGYTWIVPSLVAGDAD-HIP 129

  Fly   352 SQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDN 416
            ::||.||:.|.:|.....|...:.:.:.:.:......:.| ......|.::.....|:......|
Zfish   130 AEFPTGMISVSYDEWDYGLEARVRDGVAVIATATSTMMMD-RGPHTLLKSECHGAPDKKSPMTGN 193

  Fly   417 GEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKL 481
            .....:||.||:.||    .|:.|:.||.....:|.|:.|     :|...|:.:|   .||...|
Zfish   194 NNEVLRYLMNVTFEG----RNLSFSEDGYQMHPKLVIILL-----DKERQWDRVG---KWENGSL 246

  Fly   482 DIRDIAWPG-NSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMA 545
            .::...||. ..::.|: ..|..||.|..|||||::.:...||:||.| |...|.||
Zfish   247 SMKYHVWPRFELYSGPE-AREDDHLSIVTLEEAPFVIVEDVDPLSGTC-MRNTVPCR-------- 301

  Fly   546 ADIDVGQAHRNESFY--QCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLV 608
            ..:......::.:.|  :||.|||||:|:|.|:.:.|||:|..|.:||.|...||.|||::.::|
Zfish   302 KQLKALNQTQDSAVYIKRCCKGFCIDILKKIAKNVKFTYDLYLVTNGKHGKKINGTWNGMVGEVV 366

  Fly   609 NRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAI 673
            .:...|.:.||.||.||..|:|||.||:||||:::|::..|.:||:||||||....|:::.::.:
Zfish   367 LKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWIMMFVMLL 431

  Fly   674 QAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFM 738
            ..:...:|:||:.||.||: :............|::.:..||:|.::|..:|.|.:|||.||:.|
Zfish   432 LVSAIAVFIFEYFSPVGYN-RCLADGREAGGPSFTIGKAIWLLWGLVFNNSVPVQNPRGTTSKIM 495

  Fly   739 TNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIH 803
            .:|||.|||:|||.||||||||||..|...:.|||:|.:..:|....|.|:|||:|...|:..|.
Zfish   496 VSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQNPNDFSPPFRFGTVPNGSTERNIR 560

  Fly   804 KYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSW--YAMTG 866
            ..:..||:||.::::.:|.:.:.::..|.||:||||..||:|:..:||.|:|:|:||.  :|.||
Zfish   561 NNYRDMHSYMVKFHQRNVVEALESLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTG 625

  Fly   867 YGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLL 931
            ||:|..::|.:.:..:..:|:...:|::|.|...|:||.|...|.|..||. |.::.....|.:|
Zfish   626 YGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHHEKNEVMSSQ-LDVDNMAGVFYML 689

  Fly   932 MAGILLAALLLLLEHVYFKYIRKRLAKKDGGHC-CALISLSMGKSLTFRGAVF---EATEIL-KK 991
            .|.:.|:.:..:.|||::.::|         .| ..:.|...|.:.|....::   ...||. |.
Zfish   690 GAAMALSLITFIAEHVFYWHMR---------FCFMGVCSGKPGFTFTISREIYSCIHGVEIEDKS 745

  Fly   992 HRCNDP---ICDTH------LWKVKHELDMSRLR---------VRQLEKVMD--KH--------G 1028
            ...|.|   :.:||      |...|:...:|.:.         :|:...|.|  :|        .
Zfish   746 SALNSPSATMNNTHSNILRLLRTAKNMASLSGVNGSPHSALDFIRRESSVYDISEHRRSLAGHSD 810

  Fly  1029 IKAPQLRLASSSDLLNHHHLKERPPLLGNLSLAASAQDLYRWSY 1072
            .|||.|    ..|.:...::.|.....|||.|..|  :||:..|
Zfish   811 CKAPYL----PDDNMFSDYISEVERTFGNLHLKDS--NLYQDHY 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	75/267 (28%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	160/409 (39%)
		Lig_chan	665..928	CDD:278489	96/264 (36%)
LOC110438919	XP_021328141.1	PBP1_iGluR_NMDA_NR2	<1..255	CDD:107373	75/267 (28%)
		PBP2_iGluR_NMDA_Nr2	267..667	CDD:270436	160/409 (39%)
		DUF4013	<389..478	CDD:315788	30/89 (34%)
		NMDAR2_C	704..1417	CDD:313729	35/160 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591426
Domainoid	1	1.000	218	1.000	Domainoid score	I2585
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1644
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279143at33208
OrthoFinder	1	1.000	-	-		FOG0000775
OrthoInspector	1	1.000	-	-		otm24466
orthoMCL	1	0.900	-	-		OOG6_102799
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3072
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.790