Protein Alignment Nmdar2 and grin2ba

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_001429729.1
• Gene: grin2ba / 110438919
• ZFINID: ZDB-GENE-090821-2
• Length: 1606
• Species: Danio rerio
• Alignment Length: 1083
• Identity: 320/1083 - (29%)
• Similarity: 518/1083 - (47%)
• Gaps: 133/1083 - (12%)

  Fly    54 TPPSG----PISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGK 114
            |||:.    |....|:.|..||:|.....|..|...|||.......|          ||:....|
Zfish    24 TPPTAIRLRPSLCQLICVWLLLLLLPAVGQSRRERGGGGVAQFLPPA----------APYPPVSK 78

  Fly   115 REYLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTP----------SPTAILSTLCK 169
              .|:.::.||..:..:....:...:|..      .|...:|.|          .|.:|:.::|.
Zfish    79 --LLQGLSIAVVLVGNSSEVVMAGARDKE------EFGQAALVPGVEMLTMNETDPKSIIKSICD 135

  Fly   170 EFLRVNVSAILYMMNNEQFGHST---ASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQ 231
            ....       :.:....||..|   |.||....::....||::.....:|.:......:::..|
Zfish   136 LMTE-------HWLQGVVFGDDTDQEAIAQILDFISAQTHIPILGVKGGSSMIMAAKDDNSMFFQ 193

  Fly   232 LAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVA------EMQEHFKFTILNS 290
            ..||||.|::.||:|:|.|.|:.||:||:...|:.|||..:|..:.      |::|   ..:|:.
Zfish   194 FGPSIEQQASVMLNIMEEYDWYIFSIVTTYYPGYQDFVTKIRSTIENSFVGWELEE---VLLLDM 255

  Fly   291 IVVTRTSDLMELVNS-EARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDAH--S 352
            .|....:.:..|:.. ::.|:|||:|:.||..|.:.|..:.|||..|.|:|...|....| |  :
Zfish   256 SVDDGDAKIQNLLKKLQSPVILLYSTKEEANIIFQVAHSVGLTGYGYTWIVPSLVAGDAD-HIPA 319

  Fly   353 QFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNG 417
            :||.||:.|.:|.....|...:.:.:.:.:......:.| ......|.::.....|:......|.
Zfish   320 EFPTGMISVSYDEWDYGLEARVRDGVAVIATATSTMMMD-RGPHTLLKSECHGAPDKKSPMTGNN 383

  Fly   418 EIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLD 482
            ....:||.||:.||    .|:.|:.||.....:|.|:.|     :|...|:.:|   .||...|.
Zfish   384 NEVLRYLMNVTFEG----RNLSFSEDGYQMHPKLVIILL-----DKERQWDRVG---KWENGSLS 436

  Fly   483 IRDIAWPG-NSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAA 546
            ::...||. ..::.|: ..|..||.|..|||||::.:...||:||.| |...|.||        .
Zfish   437 MKYHVWPRFELYSGPE-AREDDHLSIVTLEEAPFVIVEDVDPLSGTC-MRNTVPCR--------K 491

  Fly   547 DIDVGQAHRNESFY--QCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVN 609
            .:......::.:.|  :||.|||||:|:|.|:.:.|||:|..|.:||.|...||.|||::.::|.
Zfish   492 QLKALNQTQDSAVYIKRCCKGFCIDILKKIAKNVKFTYDLYLVTNGKHGKKINGTWNGMVGEVVL 556

  Fly   610 RKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQ 674
            :...|.:.||.||.||..|:|||.||:||||:::|::..|.:||:||||||....|:::.::.:.
Zfish   557 KNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWIMMFVMLLL 621

  Fly   675 AATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMT 739
            .:...:|:||:.||.||: :............|::.:..||:|.::|..:|.|.:|||.||:.|.
Zfish   622 VSAIAVFIFEYFSPVGYN-RCLADGREAGGPSFTIGKAIWLLWGLVFNNSVPVQNPRGTTSKIMV 685

  Fly   740 NVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHK 804
            :|||.|||:|||.||||||||||..|...:.|||:|.:..:|....|.|:|||:|...|:..|..
Zfish   686 SVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQNPNDFSPPFRFGTVPNGSTERNIRN 750

  Fly   805 YFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSW--YAMTGY 867
            .:..||:||.::::.:|.:.:.::..|.||:||||..||:|:..:||.|:|:|:||.  :|.|||
Zfish   751 NYRDMHSYMVKFHQRNVVEALESLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGY 815

  Fly   868 GLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLM 932
            |:|..::|.:.:..:..:|:...:|::|.|...|:||.|...|.|..||. |.::.....|.:|.
Zfish   816 GIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHHEKNEVMSSQ-LDVDNMAGVFYMLG 879

  Fly   933 AGILLAALLLLLEHVYFKYIRKRLAKKDGGHC-CALISLSMGKSLTFRGAVF---EATEIL-KKH 992
            |.:.|:.:..:.|||::.::|         .| ..:.|...|.:.|....::   ...||. |..
Zfish   880 AAMALSLITFIAEHVFYWHMR---------FCFMGVCSGKPGFTFTISREIYSCIHGVEIEDKSS 935

  Fly   993 RCNDP---ICDTH------LWKVKHELDMSRLR---------VRQLEKVMD--KH--------GI 1029
            ..|.|   :.:||      |...|:...:|.:.         :|:...|.|  :|        ..
Zfish   936 ALNSPSATMNNTHSNILRLLRTAKNMASLSGVNGSPHSALDFIRRESSVYDISEHRRSLAGHSDC 1000

  Fly  1030 KAPQLRLASSSDLLNHHHLKERPPLLGNLSLAASAQDLYRWSY 1072
            |||.|    ..|.:...::.|.....|||.|..|  :||:..|
Zfish  1001 KAPYL----PDDNMFSDYISEVERTFGNLHLKDS--NLYQDHY 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	96/407 (24%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	160/409 (39%)
grin2ba	NP_001429729.1	None