Protein Alignment Nmdar2 and grik3

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_031752773.1
• Gene: grik3 / 100498426
• XenbaseID: XB-GENE-6050069
• Length: 919
• Species: Xenopus tropicalis
• Alignment Length: 944
• Identity: 223/944 - (23%)
• Similarity: 389/944 - (41%)
• Gaps: 201/944 - (21%)

  Fly   143 SFEQKNIHFDMMSLTPSPTAI-LSTLCKEFLRVN------------------VSAILYMMNNEQF 188
            |.|::...|....:..:.|.: .:||..:..|:|                  |.||        |
 Frog    54 SAEEQAFRFSASIINRNRTLLPNTTLTYDIQRINLYDSFEANRKACDQLALGVVAI--------F 110

  Fly   189 GHSTASAQYFLQ-LAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKW 252
            |.|.:|:...:| :...|.:|.|.....:..|:.|.|   ..:.|.|.....|.|:|.:::..||
 Frog   111 GPSHSSSSNAVQSICNALEVPHIQVRWKHHPLDNRDS---FYVNLYPDYASLSHAILDLVQFLKW 172

  Fly   253 HQFSVVTSQIAGHDDFVQAVRERVAEMQEHF----KFTILNSI--VVTRTSDLMELVNS-----E 306
            ...:||      :||....:|     :||..    ::.|...|  :...:.|...|:..     |
 Frog   173 RSATVV------YDDSTGLIR-----LQELIMAPARYNIRLKIRQLPPESEDARPLLKEMKRGRE 226

  Fly   307 ARVMLLYATQTEAITILRAAEEMKLTGENYVWVVS------------------------------ 341
            .|: :...:.|.|..|||.|..|.:..|.|.::.:
 Frog   227 FRI-IFDCSHTMAAQILRQAMAMGMMTEYYHYIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNP 290

  Fly   342 --QSVIEK--KDAHSQFP---VGML-GVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRR 398
              .|:::|  .:.|...|   .|:| |:.  |:.|||..:..:.:.:      .|...|     :
 Frog   291 YVSSIVDKWSMERHQATPKPESGLLDGIM--TTDAALTYDAVHIVSV------CYQRAP-----Q 342

  Fly   399 LTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRS-AELKIMNLRPSANN 462
            :|..||.|  .....|..|..|..:::....||...:  |.|.....||: .:|.|::|:...
 Frog   343 MTVNSLQC--HRHKAWRFGSRFMNFIKEAQWEGLTGR--IVFNKTSGLRTDFDLDIISLKEDG-- 401

  Fly   463 KNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPAD-PVSG 526
                .|::|.|.  .:..|:|.:.| .|......:.:..:..:..|.||| ||:....:| |:.|
 Frog   402 ----LEKVGTWN--PSDGLNITETA-RGRGPNISESLTNRTLIVTTVLEE-PYVMFKRSDTPLFG 458

  Fly   527 KCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGK 591
            |   ||                              ..|||||||:|.||.|||.|::..|||.|
 Frog   459 K---DR------------------------------FEGFCIDLLKKIAEILGFDYDIRLVEDAK 490

  Fly   592 WGTL-ENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGII-SPT 654
            :|:. |.|:||||:.:|::.|.|:.:..|.|...||.|:|||:|||..||:|:..|..|.. |..
 Frog   491 YGSQDEKGQWNGLVKELIDHKADLAVAPLTITHVREKVIDFSKPFMTLGISILYRKANGTAPSVF 555

  Fly   655 AFLEPFDTASWM--LVGIVAIQAATFMIFLF---EWLSPSGYDMKLYLQNTNVTPYRFSLFRTYW 714
            :||.|.....||  |:..:.:....|:|..|   ||     ||.......|:|....|:|..::|
 Frog   556 SFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEW-----YDAHPCNPGTDVVENNFTLLNSFW 615

  Fly   715 LVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLV 779
            .....|.|....: .|:..::|.:..:|..|.::.::.||||||||:............:|
 Frog   616 FAVGALMQQGSEL-MPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESAIDSADD---- 675

  Fly   780 HPFSHKPSFKFGTI---------PYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDS 835
              .:.:...::|.:         ..||. ||..|.:..|.:......|:: .:|:..||:.:. :
 Frog   676 --LAKQTKIEYGAVVDGATMNFFKKSHI-STFEKMWAFMSSRPSALVKSN-EEGIQRVLSADY-A 735

  Fly   836 FIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLR-R 899
            .:.:.|.::|:.  ..:|.|..:|......|||:.....|.|....:..:|:.:...::.::: |
 Frog   736 LLMESTAIEYIT--QRNCNLTQIGGLIDSKGYGIGTPMGSPYRDRISIAILQLQEADEIHKMKER 798

  Fly   900 YWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHC 964
            :|.:|.|  .::::|.:..|.::.....|::|..|::|:.::.:.|.||  .:|| .|:::....
 Frog   799 WWRSGGC--PEEKNKEASALGIQNMGGIFIVLAGGLILSVVVAMAEFVY--KLRK-TAEREQRSF 858

  Fly   965 CALISLSMGKSLTFRGAVFEATEILKKHRCNDPI 998
            |:.::..:..|||.:..|        ||:...|:
 Frog   859 CSTMADEIRLSLTCQRRV--------KHKPQPPV 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	85/411 (21%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	116/423 (27%)
grik3	XP_031752773.1	PBP1_iGluR_Kainate	37..417	CDD:380605	84/410 (20%)
		Periplasmic_Binding_Protein_Type_2	433..801	CDD:473866	113/418 (27%)