Protein Alignment Nmdar2 and grin3b

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_017952374.2
• Gene: grin3b / 100497172
• XenbaseID: XB-GENE-990106
• Length: 1005
• Species: Xenopus tropicalis
• Alignment Length: 904
• Identity: 234/904 - (25%)
• Similarity: 404/904 - (44%)
• Gaps: 113/904 - (12%)

  Fly   101 LNIGLIAPHTNFGKREYLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTP---SPTA 162
            :.:|.:.|  ::|..:  ..|.|.::.:::|           |:...|:..:::|..|   ||.:
 Frog    37 VRLGALLP--SYGHTQ--ARIQNVLSRISRT-----------SWLPYNLSLEVVSGAPRDRSPAS 86

  Fly   163 ILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQ---LAGYLGIPVISWNADNSGLERR-- 222
            :...||:..:...::|:|..         ..:.:..||   |:.:|.||.||.      ||:.
 Frog    87 LTRWLCQVLVAQGIAAVLAF---------PQAQEELLQLEFLSSFLEIPFISI------LEQEQI 136

  Fly   223 ---ASQSTLQLQL--APSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEH 282
               |:::...||:  ..|:|:......|:|:...|.:..::|.    |.....:::..:......
 Frog   137 VPLATKNPFHLQMDTQSSVENLMDIFFSVLQNSSWEEVDIITC----HPWDSASIQRYLTSNTTL 197

  Fly   283 FKFTILN------SIVVTRTSDLMELVNSEARVMLLYATQT-EAITILRAAEEMKLTGENYVWVV 340
            ...||||      |.:|.......|.:.:....||||.... .:..:.|.|.:..|....:.|::
 Frog   198 VSRTILNIHPVDESALVPFLQQHFESMKNPQFPMLLYGCDARRSSLVFRVARDCGLEAHEFHWMI 262

  Fly   341 SQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLS 405
            ...:..::......|.|:| .:.:.|...:...|.:|:.:.:..:.|.:  ....|..|....::
 Frog   263 GHPLNGEEMTTEGMPPGLL-AYGEVSRPTMEKFIRDAVGLVTRAISAAV--HVRPDLALIQSMVN 324

  Fly   406 CED-EGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAE--LKIMNL-RPSANNKNLV 466
            |.| :.:....:|....::|.|.|..|...    :.....:|...|  .:|.:| |.|..:.  .
 Frog   325 CNDKQTKQNESSGSYLSRFLANTSFSGQTG----QIYVSNNLIHTEHHYRIWSLVRDSLGDP--T 383

  Fly   467 WEEIGVWKSWETQKLDIRDIAWPG--NSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCL 529
            |..:|   .|...|:::.:..|..  ....|..|...:..|::..|.|.|::.....| ..|.|
 Frog   384 WVTVG---GWRQGKMEVEEGLWQSRIQQWEPAPGGFARTKLRVVTLVEHPFVFTREVD-ADGSC- 443

  Fly   530 MDRGVLCRVAADHEMAADIDVGQAHRNE-------SFYQCCSGFCIDLLEKFAEELGFTYELVRV 587
             ..|.:|.....:..|. :||.....|.       .:..||.|:|||||||.:|:|.|.:||..|
 Frog   444 -PAGQMCLDPRTNNSAV-LDVLFEELNSPNGSVPLEYKTCCYGYCIDLLEKLSEDLRFDFELYIV 506

  Fly   588 EDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIIS 652
            .|||:|..:..:|.||:.||::....|.:||..||:.|..|:||:.||..|.:.|:|..|.....
 Frog   507 GDGKYGARKGDRWTGLVGDLLSGAAHMAVTSFSINSARSTVIDFTSPFYSTSLGILVRMRDTASP 571

  Fly   653 PTAFLEPFDTASWMLVGI-VAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYR------FSLF 710
            ..||:.|...:.|  ||| ||:......:..:||.||.|           :||:.      ||..
 Frog   572 IGAFMWPLHWSMW--VGIFVALHITALFLTFYEWKSPFG-----------MTPHGRNRTKIFSYS 623

  Fly   711 RTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLND 775
            ....|.:|:||...|...:|:..|.|.:.|:||:|.::.|:.|||||||.|:..:.|...||::|
 Frog   624 SALNLCYAILFGRTVSSKTPKCCTGRVLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEALSGIHD 688

  Fly   776 SRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNG--NLDSFIY 838
            .:|.||   ...|:|||:..|..:..|.|.|..||||||:::..:.:|||..:...  .|::||.
 Frog   689 PKLHHP---SQGFRFGTVWESSAEQYIKKSFPEMHNYMRKFSVPATSDGVHLLKTDPPTLNAFIM 750

  Fly   839 DGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMT 903
            |..:|||.|:.|.||:|:|:|..:|:.|||:...:||......::.:..::::|.::.|...|..
 Frog   751 DKALLDYEVSIDSDCKLLTIGKPFAIEGYGIGLPQNSPLTSNISEFISRYKSSGFMDTLHDKWYK 815

  Fly   904 GT-CRPGKQEHKSSDPL--ALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKK 959
            .. |  ||:.:..::.|  .:..|...|:||..|...:.|..|:|.|.:..|..|:.::
 Frog   816 MVPC--GKRVYAVTETLQMGIYHFSGLFVLLCIGFCGSLLTSLMERVVYHLILPRIRRR 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	77/407 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	140/422 (33%)
grin3b	XP_017952374.2	PBP1_iGluR_NMDA_NR3	29..402	CDD:380600	77/410 (19%)
		PBP2_iGluR_NMDA_Nr3	418..814	CDD:270438	138/415 (33%)
		Lig_chan	580..847	CDD:459656	91/284 (32%)