Protein Alignment Nmdar2 and grin2c

DIOPT Version :9

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_012808364.2
• Gene: grin2c / 100496638
• XenbaseID: XB-GENE-993386
• Length: 1189
• Species: Xenopus tropicalis
• Alignment Length: 1043
• Identity: 315/1043 - (30%)
• Similarity: 506/1043 - (48%)
• Gaps: 158/1043 - (15%)

  Fly    63 LLLTVL--TLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAV 125
            ||||||  :.::::|      .|...||          ..||:.|:..    |...|     :.:
 Frog     8 LLLTVLGCSAVVMET------LLPRAGG----------PALNVALVFG----GSFPY-----SEL 47

  Fly   126 TGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLT-----PSPTAILSTLCKEFLRVNVSAILYMMNN 185
            .|.....|:            .::..|:.::|     ..|..:|..|| :.|| ...|:::..|
 Frog    48 VGPMMPEGS------------LSLPLDIHTVTVLVNDSGPGPLLRQLC-QALR-GAHAVVFQDN- 97

  Fly   186 EQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERY 250
              .| :.|.||....::....:|:||.:..::.:......|:..||:|.|:|.|...:|.:||.|
 Frog    98 --IG-TEAVAQILDFISSQTLVPIISISGGSAVVLSPKEPSSSFLQMAASLEQQLTVILKVLEEY 159

  Fly   251 KWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHF----KFTILNSIVVTRTSDLMELVNSEARVML 311
            ....|||:||...||..|:.|||.....:|..:    :.|:........|..::..|:  |.|:|
 Frog   160 DLGPFSVITSHYPGHRLFLSAVRALCEALQPGWGPQDELTVEPGAGPKGTQRVLRQVS--APVLL 222

  Fly   312 LYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDAHSQ-FPVGMLGVHFDTSSAALMNEIS 375
            |:.::.||..:..||.|..|.|.:::|||....|...|..:. ||||::.|..|....:|..::.
 Frog   223 LFCSRDEAEEMFIAAGEAGLLGPSHIWVVPSFTIGSPDRPAPFFPVGLVSVVTDGWRRSLRQKVQ 287

  Fly   376 NAIKIYSYGVEAYLTD----PANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKP 436
            :.|.:.:.|.:.||..    |..|...|....|...|          ..::::.|..    ....
 Frog   288 DGIAVIAAGAKNYLQRHGELPQPRGSCLAPPHLHGND----------TLYRHMMNTV----WKHR 338

  Fly   437 NIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWP----GNSHAPPQ 497
            .:.|.:.|.|....:.::.|.|     :..|||:|   .||:..:.::...||    ||     |
 Frog   339 EVSFNSQGYLLDPSMLVITLTP-----HRAWEEVG---RWESGIIRMKYPVWPRYGAGN-----Q 390

  Fly   498 GVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQC 562
            .|.:..||.:..|||.|::.:...||.:|.|:.:. |.||..::..:::.   |:.:..    .|
 Frog   391 LVTDSRHLTVATLEERPFVIVESTDPATGDCIRNT-VPCRKQSNLTLSSS---GEPYTK----LC 447

  Fly   563 CSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREA 627
            |.|||||:|:|.|..:.|:|:|..|.:||.|.|..|.|||:|.::..|:..:.:.||.||.||..
 Frog   448 CKGFCIDILKKLARTVKFSYDLYLVTNGKHGKLVRGVWNGMIGEVYYRRAHLAIGSLTINEERSE 512

  Fly   628 VVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYD 692
            :||||.||:||||:::|::..|.:||:|||||:..|.||::.::.:......:|:||:.||.|||
 Frog   513 IVDFSVPFVETGISVLVSRSNGTVSPSAFLEPYSPAVWMMMFVMCLSVVAVTVFIFEYFSPMGYD 577

  Fly   693 MKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANL 757
            ..| .....:....|::.::.||:||::|..:|.:.:|||.||:.|..|||.|||:|||.|||||
 Frog   578 QDL-SNGKRLGGPSFTIGKSLWLLWALVFNNSVPIQNPRGTTSKIMVLVWAFFAVIFLASYTANL 641

  Fly   758 AAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVA 822
            |||||..:.....|||:|.:...|....|.|:|||:|...|:..|...:..||:||.:||:.||.
 Frog   642 AAFMIQEQYIDTVSGLSDRKFQKPQEQYPPFRFGTVPNGSTERNIRTNYPDMHSYMVRYNQRSVE 706

  Fly   823 DGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKRL 885
            |.:|::..|.||:||||..||:|:..:||.|:|:|:||.  :|.||||:|..:||::.:..:..|
 Frog   707 DALASLKAGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIALQKNSRWKRPIDLAL 771

  Fly   886 LEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFK 950
            |:|..:||.:||...|::|.|:..|.|..|| .|.::.....|.:|:..:.|:.|:...||:.:.
 Frog   772 LQFLGDGDTQRLETVWLSGICQNEKNEAVSS-KLDIDNMAGVFYMLLVAMGLSLLVFSWEHLVYW 835

  Fly   951 YIRKRLAKKDGGHC----C---ALISLSMGKSLTFRGAVFEATEILKKHRCNDP-ICDTHLWKVK 1007
            .:|         ||    |   .|:.:|.|....|||    ....|:..:..|| :..|
 Frog   836 RMR---------HCMPSSCGEKGLLGISRGIYSCFRG----VESPLQDSQFPDPDVTGT------ 881

  Fly  1008 HELDMSRLRVRQLEKVMDKHGIKAPQLRLASSSDLLNHHHLKERPPLLGNLSLAASAQDLYRWSY 1072
             .:.::.|||.|..:            .|.|||             .:|. ||..::|.|..|..
 Frog   882 -PVPVNVLRVLQTAR------------DLVSSS-------------AVGG-SLENASQALRTWKQ 919

  Fly  1073 KTE 1075
            ::|
 Frog   920 RSE 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	96/408 (24%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	165/407 (41%)
		Lig_chan	665..928	CDD:278489	106/264 (40%)
grin2c	XP_012808364.2	Periplasmic_Binding_Protein_type1	30..379	CDD:415822	94/399 (24%)
		PBP2_iGluR_NMDA_Nr2	395..794	CDD:270436	165/407 (41%)
		NMDAR2_C	831..>906	CDD:402274	24/120 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2551
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1565
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279143at33208
OrthoFinder	1	1.000	-	-		FOG0000775
OrthoInspector	1	1.000	-	-		otm48169
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3072
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.190