DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and grin2d

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_031762459.1	Gene:	grin2d / 100496465	XenbaseID:	XB-GENE-1011863	Length:	1345	Species:	Xenopus tropicalis

Alignment Length:	913	Identity:	285/913 - (31%)
Similarity:	456/913 - (49%)	Gaps:	116/913 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 APHTNFGKREYLRSINNAV--TGLT----KTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILS 165
            :|...| :.|..||:|.|:  :|.:    ..|.|..|| :::|.|...|  .::....:|.:::.
Frog    27 SPFLEF-REESPRSLNVAIIFSGTSYPPESARFAPTTF-RNFSMEVNPI--SVILNDTNPRSLIL 87

  Fly   166 TLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQL 230
            .:|.....:.:..:::    |....:.:.||....::....:|:|..|..::.:.....:.:..|
Frog    88 QICDVLSSLRIHGVVF----EDDTRTESVAQILDFISAQTSMPIIGINGGSAIVLTPKEKGSTFL 148

  Fly   231 QLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNS---IV 292
            ||..|.|.|...:..:||.|.|..|:|:|:...|::|||..:     |:.....|....:   :.
Frog   149 QLGASTEQQLQVIFEVLEEYDWTSFAVITTLFPGYEDFVDYI-----ELLTDSSFIGWENRGVLT 208

  Fly   293 VTRTSD---------LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKK 348
            :..|.|         |.|:.   |:|.|||.::.||..:.:||.|..|||..|:|.:..:.:...
Frog   209 LNLTDDPSGSKLKRQLREIT---AQVRLLYCSREEADGVFKAAREAGLTGPGYIWFMVGTNLGGT 270

  Fly   349 D-AHSQFPVGMLGVHFDTSSAA----LMNEISNAIKIYSYGVEAYLTD-----PANRDRR---LT 400
            | .....|||:    |...||.    |...:.|.:.|.:.|.||...|     ..|.|.|   ||
Frog   271 DYMPEHLPVGL----FTVLSAGWKDDLHRRVQNGVAIIAKGAEALYKDFGFIPEFNNDCRAPNLT 331

  Fly   401 TQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNL 465
            ..:              |...:|..|:|..|    .:..|..||.|.:..|.::.|     ||..
Frog   332 HMN--------------ENLHRYFMNISWGG----KDFSFNEDGYLINPALVVIAL-----NKER 373

  Fly   466 VWEEIGVWKSWETQKLDIRDIAWP--GNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKC 528
            .||.:|:   ||...|.::...|.  |....|   |.:..||.:..|||.|::.:...||.:|.|
Frog   374 SWEVVGI---WEHGDLRMKYPVWSRYGKFLQP---VDDDQHLTVATLEERPFVIVEGVDPATGTC 432

  Fly   529 LMDRGVLCRVAADHEMAADIDVGQAHRNESFY--------QCCSGFCIDLLEKFAEELGFTYELV 585
            :.| .|.||             .|.:|.::..        |||.|||||:|::.::.:||||:|.
Frog   433 IRD-SVPCR-------------KQLNRTDNHLTDPIIFVKQCCKGFCIDILKRLSKTIGFTYDLY 483

  Fly   586 RVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGI 650
            .|.:||.|...:|.|||:|.::..::.||.:.||.||.||..::|||.||:||||:::|::..|.
Frog   484 LVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGT 548

  Fly   651 ISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTP--YRFSLFRTY 713
            :||:|||||:..|.|:::.::.:......:|:||:.||.||:..|   :|...|  .:|::.::.
Frog   549 VSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYFSPVGYNRSL---STGKRPGGSKFTIGKSI 610

  Fly   714 WLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRL 778
            ||:||::|..:|.|::|:|.||:.|..:||.|||:|||.||||||||||..|.....|||:|.:.
Frog   611 WLLWALVFNNSVPVENPKGTTSKIMVLIWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDKKF 675

  Fly   779 VHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVL 843
            ..|....|..||||:|...|:..|...:..||.||.:||:..|.|.:..:..|.||:||||..||
Frog   676 QRPHEQYPPLKFGTVPNGSTEKNIRSNYPDMHAYMIKYNQRHVEDALQNLKTGKLDAFIYDAAVL 740

  Fly   844 DYLVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTC 906
            :|:..:||.|:|:|:||.  :|.||||:|..:.||:.:..:..||:|..:.::|.|.|.|::|.|
Frog   741 NYMARKDEGCKLVTIGSGKVFATTGYGIALQKGSKWKRPIDLALLQFLGDDEIEMLERLWLSGIC 805

  Fly   907 RPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEH-VYFKYIRKRLAKKDGGHCCALISL 970
            ...|.|..|| .|.::.....|.:|:..:.|:.|:...|| :|:|.   |...:..|....|::.
Frog   806 HNDKIEVMSS-KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLIYWKL---RHCMRHSGKLDFLLAF 866

  Fly   971 SMG 973
            |.|
Frog   867 SRG 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	100/415 (24%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	164/417 (39%)
		Lig_chan	665..928	CDD:278489	103/266 (39%)
grin2d	XP_031762459.1	PBP1_iGluR_NMDA_NR2	38..390	CDD:380601	96/396 (24%)
		PBP2_iGluR_NMDA_Nr2	406..807	CDD:270436	164/417 (39%)
		NMDAR2_C	844..>873	CDD:402274	8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2551
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H648
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1565
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279143at33208
OrthoFinder	1	1.000	-	-		FOG0000775
OrthoInspector	1	1.000	-	-		otm48169
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160