DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and grik1

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_004912220.1	Gene:	grik1 / 100493949	XenbaseID:	XB-GENE-957124	Length:	928	Species:	Xenopus tropicalis

Alignment Length:	1017	Identity:	234/1017 - (23%)
Similarity:	398/1017 - (39%)	Gaps:	234/1017 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LLLTVLTLL--ILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAV 125
            |||..|..|  |....|.|.||:   ||...   ....|.:|:..:|             ...||
Frog    25 LLLPFLCALAAITPQASQQVLRI---GGIFE---TVENEPINVEELA-------------FKFAV 70

  Fly   126 TGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGH 190
            |.:.:.|.........|..::.|: ||  |...|..|     |.: |.:.|:|:        ||.
Frog    71 TNINRNRTLMPNTTLTYDIQRINL-FD--SFEASRRA-----CDQ-LALGVAAL--------FGP 118

  Fly   191 STASAQYFLQ-LAGYLGIPVIS--W---NADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILER 249
            |.:|:...:| :...|.:|.|.  |   :.||        :.:..:.|.|.....|.|:|.::..
Frog   119 SHSSSVSAVQSICNALEVPHIQTRWKHPSVDN--------KDSFFINLHPDYAAISRAVLELVLH 175

  Fly   250 YKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVV-----------TRTSDLMELV 303
            |.|...:||      ::|....:|     :||..|.....:|.:           .||. |.|:.
Frog   176 YSWKTVTVV------YEDSTGLIR-----LQELIKAPSRYNIKIKIRQLPSGNKDARTL-LKEMK 228

  Fly   304 NSEARVMLLYATQTEAITILRAAEEMKLTGENYVW------------------------------ 338
            .|....::...:...|..||:....|.:..|.|.:
Frog   229 KSREFYVIFDCSHETAAEILKQILSMGMMTEYYHYFFTTMDLFALDLEPYRYSGVNMTGFRLLNI 293

  Fly   339 -------VVSQSVIEKKDAHSQFPVGML-GVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANR 395
                   ||.:..:|:..|..:...|:| |:.  |:.||||.:     .:|...|      ...|
Frog   294 DNPQVSSVVEKWSMERLQAPPKPETGLLDGMM--TTDAALMYD-----AVYMVAV------ATQR 345

  Fly   396 DRRLTTQSLSCEDEGRGR-WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLR-- 457
            ..::|..||.|.   |.: |..|..|...::....:|...:.....| ||..|..::.|::|:
Frog   346 ATQMTVSSLQCH---RHKPWRFGPRFMSLIKEARWDGLTGRITFNRT-DGLRRDFDMDIISLKED 406

  Fly   458 -------PSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKF---HLKITFLEE 512
                   .:.|:.|.||:::|||.|  ...|::.|     |.......:.:..   .|.:|.:.|
Frog   407 GMEKAAGETVNHLNKVWKKVGVWNS--NTGLNMTD-----NLKDKSTNITDSLANRTLIVTTILE 464

  Fly   513 APYINLSPAD-PVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAE 576
            .||:....:| |:.|                             |:.|    .|:|:|||::.:.
Frog   465 DPYVMFRKSDKPLYG-----------------------------NDRF----EGYCLDLLKELSN 496

  Fly   577 ELGFTYELVRVEDGKWGTL-ENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGI 640
            .||||||:..|.|||:|.. :.|:|||::.:|::.|.|:.:..|.|...||.|:|||:|||..||
Frog   497 ILGFTYEVRLVVDGKYGAQNDKGEWNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGI 561

  Fly   641 AIVVAKRTGIISP--TAFLEPFDTASWM--LVGIVAIQAATFMIFLF---EWLSPSGYDMKLYLQ 698
            :|:..|..| .:|  .:||.|.....||  |:..:.:....|:|..|   ||.:|...:     .
Frog   562 SILYRKPNG-TNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCN-----P 620

  Fly   699 NTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMIT 763
            :::|....|:|..::|.....|.|....: .|:..::|.:..:|..|.::.::.||||||||:..
Frog   621 DSDVVENNFTLLNSFWFGVGALMQQGSEL-MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTV 684

  Fly   764 REEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQYNKTSVA-- 822
            ..........:|      .:.:...::|.:....|.:...|    .:..|..:|....:|::.
Frog   685 ERMESPIDSADD------LAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVKN 743

  Fly   823 --DGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRL 885
              :|:..||..:. :.:.:.|.::|:.  ..:|.|..:|......|||:.....|.|.......:
Frog   744 NDEGIQRVLTTDY-ALLMESTSIEYVT--QRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 805

  Fly   886 LEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFK 950
            |:.:..|.|..::..|..|...| :::.|.:..|.:|.....|::|.||::|:..:.:.|.:|
Frog   806 LQLQEEGKLHMMKEKWWRGNGCP-EEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY-- 867

  Fly   951 YIRKRLAKKDGGHCCALISLSMGKSLTFRGAVFEATEILKKH 992
               |.....|...|           |:| .|:.|...|..||
Frog   868 ---KSRKNSDIEQC-----------LSF-NAIMEELGISLKH 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	95/455 (21%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	105/425 (25%)
		Lig_chan	665..928	CDD:278489	56/275 (20%)
grik1	XP_004912220.1	Periplasmic_Binding_Protein_Type_1	43..438	CDD:299141	99/469 (21%)
		ANF_receptor	61..404	CDD:279440	82/409 (20%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:304360	104/417 (25%)
		Lig_chan	585..854	CDD:278489	59/284 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000