Protein Alignment Nmdar2 and grin2b

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 996
• Identity: 302/996 - (30%)
• Similarity: 484/996 - (48%)
• Gaps: 148/996 - (14%)

  Fly   147 KNIH----FDMMSLTP----------SPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQY 197
            |::|    |..:.:||          .|.:|::.:|.......|..::       ||..| ..:.
 Frog    46 KDVHEKDDFHHLPVTPRVALVTMNESDPKSIITRICDLMSDKKVQGVV-------FGDDT-DQEA 102

  Fly   198 FLQLAGYLGI----PVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVV 258
            ..|:..::.:    |::..:..:|.:.....::::..|..||||.|::.||:|:|.|.|:.||:|
 Frog   103 IAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV 167

  Fly   259 TSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLMELVNS---------------EAR 308
            |:...|:.||...||.           ||.||.|.....:::.|..|               ::.
 Frog   168 TTYFPGYQDFENKVRS-----------TIENSFVGWELEEVIHLDMSLDDNDSKIQNQLKKLQSP 221

  Fly   309 VMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKD-AHSQFPVGMLGVHFDTSSAALMN 372
            |:|||.|:.||..|...|..:.|||..|.|:|...|....| ..::||.|::.|.:|.....|..
 Frog   222 VILLYCTKEEATYIFEVAHSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYDLPA 286

  Fly   373 EISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPN 437
            .:.:.|.|.:......|::    ...:.....||.:....|.....:..:||.||:.||    .|
 Frog   287 RVRDGIAIITTAASTMLSE----HNSIPQSKSSCYNIQESRVYEAHMLKRYLINVTFEG----RN 343

  Fly   438 IEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEK 502
            :.|:.||.....:|.|:.|     |:...||.:|.:|.   :.|.::...||.....|.....:.
 Frog   344 LSFSEDGYQMHPKLVIILL-----NQQRKWERVGKYKD---RSLKMKYYVWPVFELYPNSEEHKD 400

  Fly   503 FHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNES----FYQCC 563
            .||.|..|||||::.:...||:||.| |...|.||.          .:...:|.|.    ..:||
 Frog   401 EHLSIVTLEEAPFVIVEDVDPLSGTC-MRNTVPCRK----------QIRTENRTEEGGNYIKRCC 454

  Fly   564 SGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAV 628
            .|||||:|:|.|:.:.|||:|..|.:||.|...||.|||:|.::|.::..|.:.||.||.||..|
 Frog   455 KGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVTKRAYMAVGSLTINEERSEV 519

  Fly   629 VDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDM 693
            ||||.||:||||:::|::..|.:||:||||||....|:::.::.:..:...:|:||:.||.||:.
 Frog   520 VDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNR 584

  Fly   694 KLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLA 758
            .|........| .|::.:..||:|.::|..:|.|.:|:|.||:.|.:|||.|||:|||.||||||
 Frog   585 CLADGREPGGP-SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLA 648

  Fly   759 AFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVAD 823
            ||||..|...:.|||:|.:...|....|:|:|||:|...|:..|...:..||:||.::|:.||.|
 Frog   649 AFMIQEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQRSVQD 713

  Fly   824 GVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKRLL 886
            .:.::..|.||:||||..||:|:..:||.|:|:|:||.  :|.||||:|..::|.:.:..:..:|
 Frog   714 ALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAIL 778

  Fly   887 EFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKY 951
            :...:|::|.|...|:||.|...|.|..||. |.::.....|.:|.|.:.|:.:..::||::|..
 Frog   779 QLFGDGEMEELEALWLTGICHNEKNEVMSSQ-LDIDNMAGVFYMLAAAMALSLITFIMEHLFFWQ 842

  Fly   952 IRKRLAKKDGGHC----CA-----LISLSMGKSLTFRGAVFEATEILKKHRCNDP---ICDTHLW 1004
            :|         ||    |:     :.|:|.|......|...|.    ::...|.|   :.:||
 Frog   843 LR---------HCFMGVCSGKPGVVFSISRGIYSCIHGVPIED----RQSAMNSPSATMNNTH-- 892

  Fly  1005 KVKHELDMSRLRVRQLEKVMDKHGIK-APQLRL------ASSSDLLNHH---------------- 1046
                 .::.|| :|..:.:.:..|:. :||..|      :|..|:..|.
 Frog   893 -----SNILRL-LRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSFQPEEN 951

  Fly  1047 ----HLKERPPLLGNLSLAAS 1063
                ::.|.....|||.|..|
 Frog   952 LFSDYISEVERTFGNLQLKDS 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	91/371 (25%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	167/411 (41%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	91/371 (25%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	167/411 (41%)
		NMDAR2_C	837..1449	CDD:463148	31/157 (20%)