Protein Alignment Nmdar2 and grin2a

DIOPT Version :9

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_031749422.1
• Gene: grin2a / 100489006
• XenbaseID: XB-GENE-992741
• Length: 1450
• Species: Xenopus tropicalis
• Alignment Length: 1094
• Identity: 308/1094 - (28%)
• Similarity: 511/1094 - (46%)
• Gaps: 161/1094 - (14%)

  Fly    58 GPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSIN 122
            |..:|||.|:|.                 .|.|.:||..:...|||.:|...|.:.....:||:
 Frog     2 GIFALLLYTLLY-----------------AGDLGQGAEKSFPVLNIAVILGRTRYITERDIRSL- 48

  Fly   123 NAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLT-----PSPTAILSTLCKEFLRVNVSAILYM 182
                           :.:|.|.:     ||:..:|     ..|.:|::.:|.......:..:::.
 Frog    49 ---------------WTRDMSLD-----FDVNVVTLLVNQTDPKSIITHVCDLMSGTKIHGVVFG 93

  Fly   183 MNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSIL 247
            .:.:|    .|.||....::....||::..:..:|.:.....:.:...|...||:.|:..||:|:
 Frog    94 DDTDQ----EAIAQILDFVSSQTFIPILGIHGGSSMIMADKDEMSTFFQFGASIKQQAIVMLNIM 154

  Fly   248 ERYKWHQFSVVTSQIAGHDDFVQAVRERVA------EMQEHFKFTILNSIVVTRTSDLMELVNSE 306
            |.|.||.||::||...|:.||:..::..|.      |:|.  ..|:..|....||  |.:|....
 Frog   155 EEYDWHVFSIITSTFPGYRDFISFIKTTVDNSFVGWEVQN--VITLDTSYTDART--LTQLKKIH 215

  Fly   307 ARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKD-AHSQFPVGMLGVHFDTSSAAL 370
            :.|:|||.::.||..|...|..:.|.|..:||:|...|....| ...:||.|::.|.:|.....:
 Frog   216 SSVILLYCSKDEANYIFVEARSLGLMGYGFVWIVPSLVTGNTDIIPYEFPSGLVSVSYDDWDYNI 280

  Fly   371 MNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNK 435
            ...:.:.:.|.:....|.|    .:...:.....||..:............|::.||:.:|
 Frog   281 EARVRDGLGIITTAASAML----EKHSVIPEAKTSCYAQNERNEPPLHTLHKFMINVTWDG---- 337

  Fly   436 PNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVP 500
            .::.||.||...:.:|.::.|     |.:..||::|   .||.:.|:::...|| ...|.....|
 Frog   338 KDLSFTEDGYQANPKLVVLLL-----NMDREWEKVG---KWENKSLNMKYPVWP-RITASLDSDP 393

  Fly   501 EKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSG 565
            :..||.|..|||||::.:...|.::|.|:.:. |.||......       .......|..:||.|
 Frog   394 DDNHLSIVTLEEAPFVIVENVDYLTGTCVRNT-VPCRKYFRLN-------NSTTEGTSVKKCCKG 450

  Fly   566 FCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVD 630
            ||||:|:|.::.:.|||:|..|.:||.|......|||:|.::|.::..|.:.||.||.||...||
 Frog   451 FCIDILKKLSKTVKFTYDLYLVTNGKHGKKIKNVWNGMIGEVVYKRAVMAVGSLTINEERSEAVD 515

  Fly   631 FSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKL 695
            ||.||:||||:::|::..|.:||:||||||..:.|:::.::.:..:...:|:||:.||.||:..|
 Frog   516 FSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLLVSAVAVFVFEYFSPVGYNRNL 580

  Fly   696 YLQNTNVTPY--RFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLA 758
               .....|:  .|::.:..||:|.::|..:|.|.:|:|.||:.:.::||.|||:|||.||||||
 Frog   581 ---ADGKAPHGPSFTIGKAVWLLWGLVFNNSVPVQNPKGTTSKIIVSIWAFFAVIFLASYTANLA 642

  Fly   759 AFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVAD 823
            ||||..|...:.:||:|.:...|..:.|.|:|||:|...|:..|...:..||.||.::::..|.|
 Frog   643 AFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPDMHQYMVKFHQKGVQD 707

  Fly   824 GVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWY--AMTGYGLAFSRNSKYVQMFNKRLL 886
            .:.::..|.||:||||..||:|:..:||.|:|:|:||.|  |.||||:|..:.|::.:..:..||
 Frog   708 ALVSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIALQKGSRWKRPIDLALL 772

  Fly   887 EFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKY 951
            :|..:|::|.|.:.|:||.|...|.|..||. |.::.....|.:|.|.:.|:.:..:.||:::..
 Frog   773 QFVGDGEMEELEKLWLTGICHTEKNEVMSSQ-LDIDNMAGVFYMLAAAMALSLITFVWEHLFYWK 836

  Fly   952 IRKRLAKKDGGHCCALISLSMGKSLTFRGAVFE-------------ATEILK------------- 990
            :|........|....|.|:|.|......|...|             .|.:||
 Frog   837 LRYCFTGVCTGTPGLLFSISRGIYSCIHGVHIEEKKKSPDFSFTASQTNMLKLLRASKNIANLSN 901

  Fly   991 --KHRCNDPICDTHLWKVKHELDMSRLRVRQLEKVMDKHGIKAPQLR--------------LASS 1039
              :.:||.|         |...|..:.....::.|:||..:.....|              ||..
 Frog   902 LNQSQCNSP---------KRTSDYIQRNSLLMDMVLDKGNLSYSDNRPFQQKDVYSENTYDLAML 957

  Fly  1040 S-----DLLNHHHLKERPPLLGN------LSLAASAQ--------DLYRWSYKT 1074
            |     |.||::..:.:.||..|      :.:|.||:        .|::.|.:|
 Frog   958 SGNHPKDNLNNYVFQGQHPLTLNESNPNTVEVAVSAEPKLNSRPRQLWKKSVET 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	92/402 (23%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	157/409 (38%)
		Lig_chan	665..928	CDD:278489	98/266 (37%)
grin2a	XP_031749422.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2551
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1565
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279143at33208
OrthoFinder	1	1.000	-	-		FOG0000775
OrthoInspector	1	1.000	-	-		otm48169
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070