Protein Alignment Nmdar2 and grid2

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_031759030.1
• Gene: grid2 / 100487676
• XenbaseID: XB-GENE-955038
• Length: 1007
• Species: Xenopus tropicalis
• Alignment Length: 862
• Identity: 209/862 - (24%)
• Similarity: 356/862 - (41%)
• Gaps: 188/862 - (21%)

  Fly   193 ASAQYFLQLAGYLGIPVISWNADNS-------GLERRASQSTLQLQLAPSIEHQSAAMLSILERY 250
            |||.....||..:.||.:......:       ||:|.:......|.:.|.: :.:..:|.::..|
 Frog   100 ASAGSLQSLADAMHIPHLFIQRSTARTPRSGCGLQRSSGIDDYTLSVRPPV-YLNDVILRVVTEY 163

  Fly   251 KWHQFSVV---TSQIAGHDDFVQAVRER-----VAEMQEHFKFTILNSIVVTRTSDLMELVNSEA 307
            .|.:|.|.   ...|.|..:|:..|.::     :.:::.:....|.......|..:|....::..
 Frog   164 AWQKFIVFYDNNYDIRGIQEFLDRVSQQGMDVALQKVENNINRMITGLFATMRIEELNRYRDTLR 228

  Fly   308 RVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDA--------------HSQFPVG- 357
            |.:|: .:.|.|...:....|..|...:..|::....|...|.              ...|||.
 Frog   229 RAILV-MSPTTAKAFITEVVETNLVAFDCHWIIINEEINDLDVQELVRRSIGRLTIIRQTFPVPH 292

  Fly   358 ------MLGVH-FDTSSAALMNEISNAIKI---YSYGVEAYLTDPANR---DRRL-TTQSLSCED 408
                  ..|.| ..||.....:..|..::|   |.|.....|.:..::   ||:. :..||:|..
 Frog   293 NSSQRCFRGNHRISTSLCDPKDPFSQNMEITNMYIYDTVLLLANAFHKKLEDRKWHSMASLTCIR 357

  Fly   409 EGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVW 473
            :....|..|....:.::...:.|....  ::|:.||                .|.|:.:|.:|..
 Frog   358 KNSKPWQGGRSMLETVKKGGVSGLTGA--LDFSEDG----------------GNPNIYFEILGTN 404

  Fly   474 KSWETQKLDIRDIA-WPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSG--KCLMD---- 531
            ...|..: .||.:. |                                 :||:|  ..|.|
 Frog   405 YGEELGR-GIRKLGFW---------------------------------NPVTGLNGSLTDRKLE 435

  Fly   532 ---RGVLCRVAADHE----MAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVED 589
               |||:.|||...|    |.::..:|:..:    ||   ||.||:|:..:..|||.||:....|
 Frog   436 NNMRGVVLRVATVLEEPFVMVSENVLGKPKK----YQ---GFSIDVLDALSSYLGFKYEIYVASD 493

  Fly   590 GKWGTLE-NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISP 653
            .|:|:.: :|.|||||.:|:.::.||.:::|.|..:||.||||:..:|:..:.:::.|....:..
 Frog   494 HKYGSPQADGSWNGLIGELLLKRADMGISALTITPDRENVVDFTTRYMDYSVGVLLRKAEKTVDM 558

  Fly   654 TAFLEPFDTASW-------MLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFR 711
            .|.|.|||.:.|       :|||:        :::|..||:|....|......|        |:.
 Frog   559 FACLAPFDLSLWACIAGTVLLVGL--------LVYLLNWLNPPRLQMGSMTSTT--------LYN 607

  Fly   712 TYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFM-ITREEFHEFSGLND 775
            :.|.|:....|....|.... ..:|.|...|.|||::.::.||||||||: |:|.| .....|.|
 Frog   608 SMWFVYGSFVQQGGEVPYTT-LATRMMMGAWWLFALIVISSYTANLAAFLTISRIE-SSIQSLQD 670

  Fly   776 SRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNV----------MHNYM-RQYNKTSVA------- 822
                  .|.:....:||:    .||.::::..|          |::.| |..|:::.:
 Frog   671 ------LSRQTDIPYGTV----FDSAVYEHVRVKGMNPFERDSMYSQMWRMINRSNGSENNVQES 725

  Fly   823 -DGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLL 886
             :|:..|.:||. :|::|..||:|:...|:||...|||:..|..|||:|....|.|..:|::|:|
 Frog   726 LEGIQKVKHGNY-AFVWDAAVLEYIAINDQDCSFYTVGNTIADRGYGIALQHGSPYRDIFSQRIL 789

  Fly   887 EFRANGDLERLRRYW--MTGTCRPGKQEHKSSD------PLALEQFLSAFLLLMAGILLAALLLL 943
            |.:.|||::.|:..|  ..|.|    :.|.|.|      .|.::.|...|.:|.|||:|:..:.:
 Frog   790 ELQQNGDMDILKHKWWPRNGQC----ELHSSMDTKQKGSSLDIKSFSGVFCILAAGIVLSCFIAM 850

  Fly   944 LEHVYFKYIRKRLAKKD 960
            :|..:.|....|:..|:
 Frog   851 VETWWNKKKGSRVPSKE 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	62/335 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	130/448 (29%)
grid2	XP_031759030.1	Periplasmic_Binding_Protein_type1	28..429	CDD:471960	67/382 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	122/401 (30%)