DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and grid2

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_031759030.1	Gene:	grid2 / 100487676	XenbaseID:	XB-GENE-955038	Length:	1007	Species:	Xenopus tropicalis

Alignment Length:	862	Identity:	209/862 - (24%)
Similarity:	356/862 - (41%)	Gaps:	188/862 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 ASAQYFLQLAGYLGIPVISWNADNS-------GLERRASQSTLQLQLAPSIEHQSAAMLSILERY 250
            |||.....||..:.||.:......:       ||:|.:......|.:.|.: :.:..:|.::..|
Frog   100 ASAGSLQSLADAMHIPHLFIQRSTARTPRSGCGLQRSSGIDDYTLSVRPPV-YLNDVILRVVTEY 163

  Fly   251 KWHQFSVV---TSQIAGHDDFVQAVRER-----VAEMQEHFKFTILNSIVVTRTSDLMELVNSEA 307
            .|.:|.|.   ...|.|..:|:..|.::     :.:::.:....|.......|..:|....::..
Frog   164 AWQKFIVFYDNNYDIRGIQEFLDRVSQQGMDVALQKVENNINRMITGLFATMRIEELNRYRDTLR 228

  Fly   308 RVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDA--------------HSQFPVG- 357
            |.:|: .:.|.|...:....|..|...:..|::....|...|.              ...|||.
Frog   229 RAILV-MSPTTAKAFITEVVETNLVAFDCHWIIINEEINDLDVQELVRRSIGRLTIIRQTFPVPH 292

  Fly   358 ------MLGVH-FDTSSAALMNEISNAIKI---YSYGVEAYLTDPANR---DRRL-TTQSLSCED 408
                  ..|.| ..||.....:..|..::|   |.|.....|.:..::   ||:. :..||:|..
Frog   293 NSSQRCFRGNHRISTSLCDPKDPFSQNMEITNMYIYDTVLLLANAFHKKLEDRKWHSMASLTCIR 357

  Fly   409 EGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVW 473
            :....|..|....:.::...:.|....  ::|:.||                .|.|:.:|.:|..
Frog   358 KNSKPWQGGRSMLETVKKGGVSGLTGA--LDFSEDG----------------GNPNIYFEILGTN 404

  Fly   474 KSWETQKLDIRDIA-WPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSG--KCLMD---- 531
            ...|..: .||.:. |                                 :||:|  ..|.|
Frog   405 YGEELGR-GIRKLGFW---------------------------------NPVTGLNGSLTDRKLE 435

  Fly   532 ---RGVLCRVAADHE----MAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVED 589
               |||:.|||...|    |.::..:|:..:    ||   ||.||:|:..:..|||.||:....|
Frog   436 NNMRGVVLRVATVLEEPFVMVSENVLGKPKK----YQ---GFSIDVLDALSSYLGFKYEIYVASD 493

  Fly   590 GKWGTLE-NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISP 653
            .|:|:.: :|.|||||.:|:.::.||.:::|.|..:||.||||:..:|:..:.:::.|....:..
Frog   494 HKYGSPQADGSWNGLIGELLLKRADMGISALTITPDRENVVDFTTRYMDYSVGVLLRKAEKTVDM 558

  Fly   654 TAFLEPFDTASW-------MLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFR 711
            .|.|.|||.:.|       :|||:        :::|..||:|....|......|        |:.
Frog   559 FACLAPFDLSLWACIAGTVLLVGL--------LVYLLNWLNPPRLQMGSMTSTT--------LYN 607

  Fly   712 TYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFM-ITREEFHEFSGLND 775
            :.|.|:....|....|.... ..:|.|...|.|||::.::.||||||||: |:|.| .....|.|
Frog   608 SMWFVYGSFVQQGGEVPYTT-LATRMMMGAWWLFALIVISSYTANLAAFLTISRIE-SSIQSLQD 670

  Fly   776 SRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNV----------MHNYM-RQYNKTSVA------- 822
                  .|.:....:||:    .||.::::..|          |::.| |..|:::.:
Frog   671 ------LSRQTDIPYGTV----FDSAVYEHVRVKGMNPFERDSMYSQMWRMINRSNGSENNVQES 725

  Fly   823 -DGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLL 886
             :|:..|.:||. :|::|..||:|:...|:||...|||:..|..|||:|....|.|..:|::|:|
Frog   726 LEGIQKVKHGNY-AFVWDAAVLEYIAINDQDCSFYTVGNTIADRGYGIALQHGSPYRDIFSQRIL 789

  Fly   887 EFRANGDLERLRRYW--MTGTCRPGKQEHKSSD------PLALEQFLSAFLLLMAGILLAALLLL 943
            |.:.|||::.|:..|  ..|.|    :.|.|.|      .|.::.|...|.:|.|||:|:..:.:
Frog   790 ELQQNGDMDILKHKWWPRNGQC----ELHSSMDTKQKGSSLDIKSFSGVFCILAAGIVLSCFIAM 850

  Fly   944 LEHVYFKYIRKRLAKKD 960
            :|..:.|....|:..|:
Frog   851 VETWWNKKKGSRVPSKE 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	64/341 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	130/448 (29%)
		Lig_chan	665..928	CDD:278489	82/297 (28%)
grid2	XP_031759030.1	Periplasmic_Binding_Protein_type1	28..429	CDD:415822	67/382 (18%)
grid2	XP_031759030.1	PBP2_iGluR_delta_2	440..806	CDD:270449	122/401 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910