Protein Alignment Nmdar2 and grin2cb

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_009305071.3
• Gene: grin2cb / 100333648
• ZFINID: ZDB-GENE-100308-2
• Length: 1328
• Species: Danio rerio
• Alignment Length: 985
• Identity: 291/985 - (29%)
• Similarity: 490/985 - (49%)
• Gaps: 127/985 - (12%)

  Fly   159 SPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNS-GLERR 222
            :|.|:|:.||:.....::..:::    |....|.|.||....::....||::..:..:: .:..:
Zfish    81 NPRALLTRLCQTMAAESLHGVVF----EDDVDSEAVAQILDFVSSQTSIPIVGISGGSAVVIPHK 141

  Fly   223 ASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRE------RVAEMQE 281
            |..||. ||:..||:.|..||..::|.|.|..|.|:||...|::.||..:|.      .:.|:|:
Zfish   142 ADGSTF-LQMGASIDQQINAMFKVMEEYNWGNFVVITSLYPGYETFVDYIRSFTDTSYFLWELQD 205

  Fly   282 HFKFTILNSIVVTRTSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIE 346
            ...|.:.......||..|::.|:|:  |.|:|.:..||..:.|.|.::.|.|..|:|:|....:.
Zfish   206 VLSFEMSVGANDIRTRRLLQQVDSQ--VYLVYCSHEEAQYLFRMASDVGLLGPGYIWIVPSLAVG 268

  Fly   347 KKDA--HSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLS-CED 408
            ..:|  .:.||||::.:..|.....|...:...:.|...||.::     ::.|....:..| |..
Zfish   269 NPEAAPPASFPVGVISIITDRWRKTLRQRVREGVAIIVKGVHSF-----HKHRGFIPEGHSDCSS 328

  Fly   409 EGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVW 473
            ..:...:|.  .|:::.|||.|    ..::.|.:||.|.:..:.|:.|     ::...|:::|
Zfish   329 PVKSYANNS--LFRHMLNVSWE----HKDLSFNSDGYLTNPSMVIIAL-----DRENHWDKVG-- 380

  Fly   474 KSWETQKLDIRDIAWP--GNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLC 536
             |:|...|.:|...||  |:...|   |.:..||.:..|||.|::.:...||.:|.|:.:. |.|
Zfish   381 -SYEGGILQMRYPVWPRYGSFLEP---VSDNRHLTVATLEERPFVIVESVDPATGTCVRNT-VPC 440

  Fly   537 RVAADHEMAADIDVGQAHRNESFY--------QCCSGFCIDLLEKFAEELGFTYELVRVEDGKWG 593
            |             .|::|.||..        .||.|||||:|:|.:..:.|:|:|..|.:||.|
Zfish   441 R-------------RQSNRTESIIGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHG 492

  Fly   594 TLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLE 658
            .:..|.|||:|.::..::.||.:.||.||.||..:||||.||:||||:::||:..|.:||:||||
Zfish   493 KMVRGVWNGMIGEVFYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLE 557

  Fly   659 PFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQA 723
            |:..|.|:::.::.:......:|:||:.||.||:..|........| .|::.::.||:|.::|..
Zfish   558 PYSPAVWVMMFVMCLTVVAVTVFVFEYFSPVGYNRSLVSAKAPGGP-TFTIGKSVWLLWGIVFNN 621

  Fly   724 AVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSF 788
            :|.:::|:|.||:.|..|||.|||:|||.||||||||||..:.....|||:|.:...|..|.|.|
Zfish   622 SVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEHYPPF 686

  Fly   789 KFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDC 853
            :|||:|...|:..|...:..||.:|.:||:..|.:.:.::..|.||:||||..||:|:..:||.|
Zfish   687 RFGTVPNGSTERNIRSNYPDMHTHMIKYNQKGVEEALNSLKTGKLDAFIYDAAVLNYMAGKDEGC 751

  Fly   854 RLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSS 916
            :|:|:||.  :|.||||:|..::|::.:..:..||:|..:||.:||...|::|.|:..|.|..||
Zfish   752 KLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWLSGICQNEKNEVMSS 816

  Fly   917 DPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMGKSLTFRG- 980
             .|.::.....|.:|:..:.|:.|:...||:.:..:|..:.|.|  ....|:::|.|....|.|
Zfish   817 -KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWKLRHSVHKSD--RLDFLLAISRGIYSCFNGV 878

  Fly   981 ---------------AVFEATEILKKHRCNDPICDTHLWKVKHELDMSRLRVRQLEKVMDKHGIK 1030
                           |.:....:||..:....|..:.  ||::.||.:   .:.:|....:.|..
Zfish   879 EDIGRSTGIQNPDITANYAQANMLKMLQTAKDIVSSA--KVENSLDNA---TKTIENWSRRSGSL 938

  Fly  1031 APQLRLASSSDLL------------NH--------------HHLKERPPLLGN-----------L 1058
            ..::.|.::::.:            ||              |.....|||:.|           .
Zfish   939 PARIPLVTTTEKVPGHFSYIANVAENHIPHMQRSITPPFTQHTTTTSPPLMVNHRVLTRPTPLRY 1003

  Fly  1059 SLAASAQDLY 1068
            :|.|..:.||
Zfish  1004 TLPARTRGLY 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	83/335 (25%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	161/415 (39%)
grin2cb	XP_009305071.3	None