DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and grin2cb

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_009305071.2	Gene:	grin2cb / 100333648	ZFINID:	ZDB-GENE-100308-2	Length:	1328	Species:	Danio rerio

Alignment Length:	985	Identity:	291/985 - (29%)
Similarity:	490/985 - (49%)	Gaps:	127/985 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 SPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNS-GLERR 222
            :|.|:|:.||:.....::..:::    |....|.|.||....::....||::..:..:: .:..:
Zfish    81 NPRALLTRLCQTMAAESLHGVVF----EDDVDSEAVAQILDFVSSQTSIPIVGISGGSAVVIPHK 141

  Fly   223 ASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRE------RVAEMQE 281
            |..||. ||:..||:.|..||..::|.|.|..|.|:||...|::.||..:|.      .:.|:|:
Zfish   142 ADGSTF-LQMGASIDQQINAMFKVMEEYNWGNFVVITSLYPGYETFVDYIRSFTDTSYFLWELQD 205

  Fly   282 HFKFTILNSIVVTRTSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIE 346
            ...|.:.......||..|::.|:|:  |.|:|.:..||..:.|.|.::.|.|..|:|:|....:.
Zfish   206 VLSFEMSVGANDIRTRRLLQQVDSQ--VYLVYCSHEEAQYLFRMASDVGLLGPGYIWIVPSLAVG 268

  Fly   347 KKDA--HSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLS-CED 408
            ..:|  .:.||||::.:..|.....|...:...:.|...||.::     ::.|....:..| |..
Zfish   269 NPEAAPPASFPVGVISIITDRWRKTLRQRVREGVAIIVKGVHSF-----HKHRGFIPEGHSDCSS 328

  Fly   409 EGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVW 473
            ..:...:|.  .|:::.|||.|    ..::.|.:||.|.:..:.|:.|     ::...|:::|
Zfish   329 PVKSYANNS--LFRHMLNVSWE----HKDLSFNSDGYLTNPSMVIIAL-----DRENHWDKVG-- 380

  Fly   474 KSWETQKLDIRDIAWP--GNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLC 536
             |:|...|.:|...||  |:...|   |.:..||.:..|||.|::.:...||.:|.|:.:. |.|
Zfish   381 -SYEGGILQMRYPVWPRYGSFLEP---VSDNRHLTVATLEERPFVIVESVDPATGTCVRNT-VPC 440

  Fly   537 RVAADHEMAADIDVGQAHRNESFY--------QCCSGFCIDLLEKFAEELGFTYELVRVEDGKWG 593
            |             .|::|.||..        .||.|||||:|:|.:..:.|:|:|..|.:||.|
Zfish   441 R-------------RQSNRTESIIGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHG 492

  Fly   594 TLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLE 658
            .:..|.|||:|.::..::.||.:.||.||.||..:||||.||:||||:::||:..|.:||:||||
Zfish   493 KMVRGVWNGMIGEVFYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLE 557

  Fly   659 PFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQA 723
            |:..|.|:::.::.:......:|:||:.||.||:..|........| .|::.::.||:|.::|..
Zfish   558 PYSPAVWVMMFVMCLTVVAVTVFVFEYFSPVGYNRSLVSAKAPGGP-TFTIGKSVWLLWGIVFNN 621

  Fly   724 AVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSF 788
            :|.:::|:|.||:.|..|||.|||:|||.||||||||||..:.....|||:|.:...|..|.|.|
Zfish   622 SVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEHYPPF 686

  Fly   789 KFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDC 853
            :|||:|...|:..|...:..||.:|.:||:..|.:.:.::..|.||:||||..||:|:..:||.|
Zfish   687 RFGTVPNGSTERNIRSNYPDMHTHMIKYNQKGVEEALNSLKTGKLDAFIYDAAVLNYMAGKDEGC 751

  Fly   854 RLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSS 916
            :|:|:||.  :|.||||:|..::|::.:..:..||:|..:||.:||...|::|.|:..|.|..||
Zfish   752 KLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWLSGICQNEKNEVMSS 816

  Fly   917 DPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMGKSLTFRG- 980
             .|.::.....|.:|:..:.|:.|:...||:.:..:|..:.|.|  ....|:::|.|....|.|
Zfish   817 -KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWKLRHSVHKSD--RLDFLLAISRGIYSCFNGV 878

  Fly   981 ---------------AVFEATEILKKHRCNDPICDTHLWKVKHELDMSRLRVRQLEKVMDKHGIK 1030
                           |.:....:||..:....|..:.  ||::.||.:   .:.:|....:.|..
Zfish   879 EDIGRSTGIQNPDITANYAQANMLKMLQTAKDIVSSA--KVENSLDNA---TKTIENWSRRSGSL 938

  Fly  1031 APQLRLASSSDLL------------NH--------------HHLKERPPLLGN-----------L 1058
            ..::.|.::::.:            ||              |.....|||:.|           .
Zfish   939 PARIPLVTTTEKVPGHFSYIANVAENHIPHMQRSITPPFTQHTTTTSPPLMVNHRVLTRPTPLRY 1003

  Fly  1059 SLAASAQDLY 1068
            :|.|..:.||
Zfish  1004 TLPARTRGLY 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	86/342 (25%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	161/415 (39%)
		Lig_chan	665..928	CDD:278489	99/264 (38%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	85/340 (25%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	161/415 (39%)
		NMDAR2_C	845..>932	CDD:313729	18/93 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591805
Domainoid	1	1.000	218	1.000	Domainoid score	I2585
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1644
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279143at33208
OrthoFinder	1	1.000	-	-		FOG0000775
OrthoInspector	1	1.000	-	-		otm24466
orthoMCL	1	0.900	-	-		OOG6_102799
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3072
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.830