DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and gria3

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001106494.1	Gene:	gria3 / 100127683	XenbaseID:	XB-GENE-1010483	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	978	Identity:	230/978 - (23%)
Similarity:	377/978 - (38%)	Gaps:	244/978 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LTLLILDTRSCQGLRLT-NGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKT 131
            |.||.|...||.|...| |.||...:..           |..|:.|.....|.:.|...|    .
Frog    11 LLLLSLVGESCGGFPNTINIGGLFMRNT-----------IQEHSAFLFAVQLHNTNQNNT----E 60

  Fly   132 RGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG-HSTASA 195
            |..:|....|        |.|    :.:..::.:..|.:|.| .|.||        || :...|.
Frog    61 RPFQLFHHVD--------HLD----SSNSFSVTNAFCSQFSR-GVYAI--------FGFYDQMSM 104

  Fly   196 QYFLQLAGYLGIPVI--SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVV 258
            .......|.|....|  |:..|        :.....:|:.|.::   .|:|::|..|.|.:|..:
Frog   105 NTLTSFCGALHTSFITPSFPTD--------ADVQFVIQMRPPLK---GAILTLLNEYDWQKFVYL 158

  Fly   259 TSQIAGHDDFVQAVRERVAEMQEHFKFT---ILNSIVVTRTSDLMELVNSEARVMLLYATQTEAI 320
            .....|. ..:||:.|  |.:|.:::.|   :.|...|.....::|.::.......:...:.|.|
Frog   159 YDTERGF-SILQAIME--AAVQNNWQVTARSVGNIKDVQEFKRIIEEMDRRQEKRFVIDCEVERI 220

  Fly   321 -TILRAAEEMKLTGEN---YVWVVSQSVIEKKDAHSQFPVGMLGVHFD---------TSSAALMN 372
             |||   |::.:.|::   |.::::.             :|..|...:         |....:.|
Frog   221 NTIL---EQVVILGKHTRGYHYMLAN-------------LGFTGFTLERVMHGGANVTGFQIVNN 269

  Fly   373 EISNAIKIYSYGVEAYLTDPANRDRR---------------LTTQSLSCEDEGRGRWDNGEIFFK 422
            |  |.|      |:.:|......|.|               ||..::....|.          |:
Frog   270 E--NPI------VQQFLQRWVRLDEREFPEARNTPLKYTSALTHDAVLVIAEA----------FR 316

  Fly   423 YLRNVSIE-------GD-LNKPNIEFTADGDLRSAELKIMNLRPSANNKNL------------VW 467
            |||...::       || |..|.:.::...|:..| ||::.::....|...            |:
Frog   317 YLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERA-LKMVQVQGMTGNIQFDTYGRRTNYTIDVY 380

  Fly   468 E-------EIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVS 525
            |       ::|.|..:|      |.:..|...........|...:.:|.:.|.||:
Frog   381 EMTATKPRKVGHWNEYE------RFVPAPDQQPTNESSSVENKTIIVTTILENPYV--------- 430

  Fly   526 GKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDG 590
                |.:       .:||:   :|     .|:.:    .|:|:||..:.|:.:|..|:|..||||
Frog   431 ----MKK-------KNHEL---LD-----GNDKY----EGYCVDLASEIAKHVGIKYKLSIVEDG 472

  Fly   591 KWGTL--ENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTG 649
            |:|..  |...|||::.:||..:.|:.:..|.|...||.|:|||:|||..||:|::.|    :.|
Frog   473 KYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 537

  Fly   650 IISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLY-------LQNTNVTPYRF 707
            :.|   ||:|.....||.: :.|....:.::||....||  |:..|.       .||....|..|
Frog   538 VFS---FLDPLAYEIWMCI-VFAYIGVSVVLFLVSRFSP--YEWHLEDTDEARDPQNPPDPPNEF 596

  Fly   708 SLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSG 772
            .:|.:.|.......|....: |||..:.|.:..||..|.::.::.||||||||
Frog   597 GIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------ 648

  Fly   773 LNDSRLVHP------FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQ-----YNKTSVA 822
            |...|:|.|      .:.:....:||:....|.....:    .:..|.:||:.     :.||: .
Frog   649 LTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTT-D 712

  Fly   823 DGVAAV--LNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRL 885
            ||||.|  ..|.. :|:.:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:
Frog   713 DGVARVRKSKGKF-AFLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAV 775

  Fly   886 LEFRANGDLERLRRYWM--TGTCRPGKQEHKSSD---PLALEQFLSAFLLLMAGILLAALLLLLE 945
            |:....|.|::|:..|.  .|.|  |.::..|.|   .|:|......|.:|:.|:.||.::.|:|
Frog   776 LKLSEQGILDKLKNKWWYDKGEC--GAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 838

  Fly   946 HVY 948
            ..|
Frog   839 FCY 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	84/451 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	120/437 (27%)
		Lig_chan	665..928	CDD:278489	75/291 (26%)
gria3	NP_001106494.1	Periplasmic_Binding_Protein_Type_1	29..400	CDD:324556	87/461 (19%)
gria3	NP_001106494.1	PBP2_iGluR_AMPA	416..798	CDD:270433	119/435 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000