DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and ZFYVE16

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_001098721.2	Gene:	ZFYVE16 / 9765	HGNCID:	20756	Length:	1539	Species:	Homo sapiens

Alignment Length:	226	Identity:	65/226 - (28%)
Similarity:	96/226 - (42%)	Gaps:	56/226 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 IMPLEEVSLESIADNQTYRNGWYIRTTT-----KSFVVFAATSTEKQEWMAHINKCVEDLLRKSG 138
            ::|: ..:::|.||.|...|..||...:     .|||.....|..:       |.|.|.|: ...
Human   684 VVPI-TCAIDSTADPQVSFNSNYIDIESNSEGGSSFVTANEDSVPE-------NTCKEGLV-LGQ 739

  Fly   139 KKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKALRV 203
            |:|      .||||::|..||:| :.:|||.:||||||.||.|.|..|..:|..| |...|..||
Human   740 KQP------TWVPDSEAPNCMNC-QVKFTFTKRRHHCRACGKVFCGVCCNRKCKL-QYLEKEARV 796

  Fly   204 CDACYERLKHVPSSLGSGEDSAAATGAASGNKLNTTAGDSSNDEDSDE-ETASPGGESHDEPRFY 267
            |..|||.:                :.|.:..::.:..|.:.....||| .|..|..|:
Human   797 CVVCYETI----------------SKAQAFERMMSPTGSNLKSNHSDECTTVQPPQEN------- 838

  Fly   268 GDNSVLSAVEDSSTITSPSSATTGSLEAPQV 298
                      .:|:|.||::....:|:.|.|
Human   839 ----------QTSSIPSPATLPVSALKQPGV 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	13/54 (24%)
		PH	39..131	CDD:278594	14/56 (25%)
		FYVE_PKHF	148..208	CDD:277257	29/59 (49%)
ZFYVE16	NP_001098721.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..491
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..678
		FYVE_endofin	738..804	CDD:277268	34/73 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	816..850		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	884..907
		DUF3480	1167..1515	CDD:371829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940