DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and ZFYVE9

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_004790.2	Gene:	ZFYVE9 / 9372	HGNCID:	6775	Length:	1425	Species:	Homo sapiens

Alignment Length:	294	Identity:	74/294 - (25%)
Similarity:	112/294 - (38%)	Gaps:	86/294 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 NIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRT-----TTKSFVVFAATSTEKQEWMAH 125
            |.::||.|..:.....:...||.:|::..|  ||.::.:     :|:..:..|..|.:..
Human   615 NDILGKAKLGENSATNVCSPSLGNISNVDT--NGEHLESYEAEISTRPCLALAPDSPDND----- 672

  Fly   126 INKCVEDLLRK-----SGKKP---VENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVV 182
                    ||.     |.:||   :...|.|||||:.|..||.| :.:|||.:||||||.||.|.
Human   673 --------LRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKC-EARFTFTKRRHHCRACGKVF 728

  Fly   183 CAGCSAKKFLLPQQSTKALRVCDACYERLKHV-------------PSSLGSGE--------DSAA 226
            ||.|.:.|..|.....|..|||..|:..|.:.             |:.....|        ..|.
Human   729 CASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCSTIPPLQQAQ 793

  Fly   227 ATGAASGNKLNTTAGDSSNDEDSDEETA--------SPGGE---SHDEPRFYGDNSVL--SAVED 278
            |:||.|                |...|.        .||.|   ..::.|.:..:.:|  ..|.|
Human   794 ASGALS----------------SPPPTVMVPVGVLKHPGAEVAQPREQRRVWFADGILPNGEVAD 842

  Fly   279 SSTITSPSSATTGSLEAPQVTPSVQSSPAAVATT 312
            ::.:|...:::.|:|       :|...|....||
Human   843 AAKLTMNGTSSAGTL-------AVSHDPVKPVTT 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	13/67 (19%)
		PH	39..131	CDD:278594	13/69 (19%)
		FYVE_PKHF	148..208	CDD:277257	30/59 (51%)
ZFYVE9	NP_004790.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..255
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..352
		FYVE_endofin	690..757	CDD:277268	32/67 (48%)
		SBD	767..823		12/71 (17%)
		SARA	773..811	CDD:314365	9/53 (17%)
		DUF3480	1048..1400	CDD:314798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940