DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and PIB1

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_010599.1	Gene:	PIB1 / 851908	SGDID:	S000002721	Length:	286	Species:	Saccharomyces cerevisiae

Alignment Length:	203	Identity:	56/203 - (27%)
Similarity:	83/203 - (40%)	Gaps:	37/203 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 KKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKAL-- 201
            |:...|:.|.|..|.:|..|..| ||.|:|:.||||||.||.:.|:.|:.......::...||
Yeast     4 KEDCINNLARWQADEEAHSCFQC-KTNFSFLVRRHHCRCCGRIFCSSCTENFVNYNKKRVHALQK 67

  Fly   202 ----------RVCDACYERLKHVPSSLGS-GEDSAAATGAASGNKLNTTAGDSSNDEDSD----- 250
                      |.|:.||:.|.|:...:.| ..|...:..:...|.|..:|.||:.|||::
Yeast    68 KNSDVESPPYRTCNECYDNLLHLNLLVSSTNRDVRLSQTSVPPNALALSAPDSNTDEDAEILEDS 132

  Fly   251 ---------EETASPGGESH-------DEPRFYGDNSVLSAVEDSSTITSPSSATTGSLEAPQVT 299
                     .|.:|...|.|       |..:|..:......|||.......:...|.:.:|  ..
Yeast   133 VDQSGTACRSEESSQNEEDHFCPICNSDLTQFPDEEETRKHVEDCIQRAENAQQHTNTSDA--AD 195

  Fly   300 PSVQSSPA 307
            .||:.|||
Yeast   196 DSVKESPA 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927
		PH	39..131	CDD:278594
		FYVE_PKHF	148..208	CDD:277257	23/71 (32%)
PIB1	NP_010599.1	FYVE	12..89	CDD:214499	27/77 (35%)
		RNF220	94..>198	CDD:406370	21/105 (20%)
		mRING-CH-C4HC2H_ZNRF	224..260	CDD:319403
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1729
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	70	1.000	Inparanoid score	I1698
Isobase	1	0.950	-	0.864974	Normalized mean entropy	S1591
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto100071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	1	1.000	-	-		X3637
TreeFam	0	0.000	Not matched by this tool.
	7	6.840