DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rush and PLEKHF2

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_078889.1	Gene:	PLEKHF2 / 79666	HGNCID:	20757	Length:	249	Species:	Homo sapiens

Alignment Length:	256	Identity:	160/256 - (62%)
Similarity:	191/256 - (74%)	Gaps:	11/256 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDRLVNSEANTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYG 65
            |||||.|||||||||:.||||||::|.||.:.||||:|||||||:|||:||:|||||||||||||
Human     1 MVDRLANSEANTRRISIVENCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYG 65

  Fly    66 NIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCV 130
            ||||.|||||||||:|||.|:::||.|....||||.|:|.||||.|:|||:|||.|||.||||||
Human    66 NIVIQKKKYNKQHIIPLENVTIDSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCV 130

  Fly   131 EDLLRKSGKKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQ 195
            .|||.||||.|...||||||||::|:|||.|:|.:||.:.||||||.||.|||..||.|:||||.
Human   131 TDLLSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPS 195

  Fly   196 QSTKALRVCDACYERLKHVPSSLGSGEDSAAATGAAS---GNKLNTTAGDSSNDEDSDEET 253
            ||:|.:|:||.||:.|        |..|.|....|.|   ...|.:...|.|:|:|.|:.:
Human   196 QSSKPVRICDFCYDLL--------SAGDMATCQPARSDSYSQSLKSPLNDMSDDDDDDDSS 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	90/121 (74%)
		PH	39..131	CDD:278594	69/91 (76%)
		FYVE_PKHF	148..208	CDD:277257	37/59 (63%)
PLEKHF2	NP_078889.1	PH_Phafin2-like	7..129	CDD:269927	90/121 (74%)
		FYVE_PKHF2	148..211	CDD:277294	39/62 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..249		8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158266
Domainoid	1	1.000	152	1.000	Domainoid score	I4330
eggNOG	1	0.900	-	-		E1_KOG1729
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11620
Inparanoid	1	1.050	333	1.000	Inparanoid score	I2426
Isobase	1	0.950	-	0.864974	Normalized mean entropy	S1591
OMA	1	1.010	-	-		QHG52283
OrthoDB	1	1.010	-	-		D1237900at2759
OrthoFinder	1	1.000	-	-		FOG0002686
OrthoInspector	1	1.000	-	-		oto91059
orthoMCL	1	0.900	-	-		OOG6_105889
Panther	1	1.100	-	-	LDO	PTHR46280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	1	1.000	-	-		X3637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750