DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and FYCO1

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_001373350.1	Gene:	FYCO1 / 79443	HGNCID:	14673	Length:	1478	Species:	Homo sapiens

Alignment Length:	265	Identity:	68/265 - (25%)
Similarity:	109/265 - (41%)	Gaps:	51/265 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 YNK--QHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCVEDLLRK 136
            |||  |.:...|....:.:||......       ||.::         :|.:..:.:..:.|.:|
Human  1106 YNKLCQEVTNRERNDQKMLADLDDLNR-------TKKYL---------EERLIELLRDKDALWQK 1154

  Fly   137 SGKKPVENHAAV---WVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQST 198
            |.....:...:.   |:.||:|:.|:.||: :|:::.||||||.||.:.|..| ...::|.:...
Human  1155 SDALEFQQKLSAEERWLGDTEANHCLDCKR-EFSWMVRRHHCRICGRIFCYYC-CNNYVLSKHGG 1217

  Fly   199 KALRVCDACYERLKHVPSSLGS-------GEDSAAATGAASGNKLNTTAGDSSN----------- 245
            |..|.|.||:::|...|.|..|       ||.|.|.:.|:.|.:  .|.|..:|
Human  1218 KKERCCRACFQKLSEGPGSPDSSGSGTSQGEPSPALSPASPGPQ--ATGGQGANTDYRPPDDAVF 1280

  Fly   246 DEDSDEETA--SPGGESHDEPRFYGDNSVLSAVEDSSTITSPSSATTGSLEAPQVTPSVQSSPAA 308
            |..:|||..  ...|.|..|.....|:...:|.|..:|.||.:...|..:      |..|.|...
Human  1281 DIITDEELCQIQESGSSLPETPTETDSLDPNAAEQDTTSTSLTPEDTEDM------PVGQDSEIC 1339

  Fly   309 VATTG 313
            :..:|
Human  1340 LLKSG 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	10/56 (18%)
		PH	39..131	CDD:278594	10/58 (17%)
		FYVE_PKHF	148..208	CDD:277257	23/62 (37%)
FYCO1	NP_001373350.1	RUN	59..164	CDD:413440
		SMC_prok_B	243..1050	CDD:274008
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..613
		PRK11281	978..>1164	CDD:236892	13/73 (18%)
		FYVE_FYCO1	1170..1227	CDD:277265	23/58 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1231..1277		12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1294..1332		10/43 (23%)
		GOLD_2	<1419..1464	CDD:404736
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1729
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840