DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and PLEKHF1

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	XP_005259313.1	Gene:	PLEKHF1 / 79156	HGNCID:	20764	Length:	364	Species:	Homo sapiens

Alignment Length:	278	Identity:	139/278 - (50%)
Similarity:	181/278 - (65%)	Gaps:	5/278 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDRLVNSEANTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYG 65
            |||.|.|:|.|::|||:||:|||:||.|||:.||||:|||||||.|||:.|.|.|||||||||||
Human    86 MVDHLANTEINSQRIAAVESCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYG 150

  Fly    66 NIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCV 130
            :||:.|:||..|||:|||||:||.:.:....:|.|.|:|..|||||.||::||:|||::||.:||
Human   151 SIVLNKRKYRSQHIIPLEEVTLELLPETLQAKNRWMIKTAKKSFVVSAASATERQEWISHIEECV 215

  Fly   131 EDLLRKSGKKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQ 195
            ...||.:|:.|...|||.|:||....:||.|.:|:|:.:.||||||.||.||||.||.::||||:
Human   216 RRQLRATGRPPSTEHAAPWIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPR 280

  Fly   196 QSTKALRVCDACYERLKHVPSSLGSGEDSAAATGAASGNKLNTTAGDSSNDEDSDEETASPGGES 260
            .|.|.:|||..||..|........:.|..|.:.|..:..........|.:|:||||:  ..|...
Human   281 LSPKPVRVCSLCYRELAAQQRQEEAEEQGAGSPGQPAHLARPICGASSGDDDDSDED--KEGSRD 343

  Fly   261 HDEP---RFYGDNSVLSA 275
            .|.|   .||......||
Human   344 GDWPSSVEFYASGVAWSA 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	76/121 (63%)
		PH	39..131	CDD:278594	56/91 (62%)
		FYVE_PKHF	148..208	CDD:277257	31/59 (53%)
PLEKHF1	XP_005259313.1	PH_Phafin2-like	92..214	CDD:269927	76/121 (63%)
		PH	124..216	CDD:278594	56/91 (62%)
		FYVE_PKHF1	233..296	CDD:277293	33/62 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1729
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52283
OrthoDB	1	1.010	-	-		D1237900at2759
OrthoFinder	1	1.000	-	-		FOG0002686
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105889
Panther	1	1.100	-	-	O	PTHR46280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.790