DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and Plekhf1

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_077724.2	Gene:	Plekhf1 / 72287	MGIID:	1919537	Length:	279	Species:	Mus musculus

Alignment Length:	283	Identity:	140/283 - (49%)
Similarity:	184/283 - (65%)	Gaps:	15/283 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDRLVNSEANTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYG 65
            |||.|.|:|.|::|||:||:|||:||.|||:.||||:|||||||.|||:.|.|.|||||||||||
Mouse     1 MVDHLANTEINSQRIAAVESCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYG 65

  Fly    66 NIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCV 130
            :||:.|:||..|||:|||||:||.:.:....:|.|.|:|..|||||.||::||:|||::||.:||
Mouse    66 SIVLSKRKYRSQHIIPLEEVTLEPLPETLQAKNRWMIKTAKKSFVVSAASTTERQEWISHIEECV 130

  Fly   131 EDLLRKSGKKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQ 195
            ...|..:|::|...|||.|:||....:||.|.:|:|:.:.||||||.||.||||.||.::||||:
Mouse   131 RRQLLATGRQPTTEHAAPWIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRERFLLPR 195

  Fly   196 QSTKALRVCDACYERL------KHVPSSLGSGEDSAAATGAASGNKLNTTAGDSS-NDEDSDEET 253
            .|.|.||||..||..|      :.....:|......:..|       .|..|.|| :|:||||:.
Mouse   196 LSPKPLRVCSLCYRELAAQKLREEAREGIGGSPPQLSHLG-------GTVCGASSGDDDDSDEDR 253

  Fly   254 ASPG-GESHDEPRFYGDNSVLSA 275
            ...| |:...:..||......||
Mouse   254 EGNGDGDWPTQVEFYASGVSWSA 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	76/121 (63%)
		PH	39..131	CDD:278594	56/91 (62%)
		FYVE_PKHF	148..208	CDD:277257	32/59 (54%)
Plekhf1	NP_077724.2	PH_Phafin2-like	7..129	CDD:269927	76/121 (63%)
		FYVE_PKHF1	148..211	CDD:277293	34/62 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..263		13/49 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10546
eggNOG	1	0.900	-	-		E1_KOG1729
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52283
OrthoDB	1	1.010	-	-		D1237900at2759
OrthoFinder	1	1.000	-	-		FOG0002686
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105889
Panther	1	1.100	-	-	O	PTHR46280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790