DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and fgd6

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_001093450.1	Gene:	fgd6 / 556459	ZFINID:	ZDB-GENE-041210-200	Length:	1315	Species:	Danio rerio

Alignment Length:	276	Identity:	88/276 - (31%)
Similarity:	125/276 - (45%)	Gaps:	53/276 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYGN-IVIGKKKYNKQHIMPLEEVSLESIAD 92
            :...|||.:.||.|.|:.||..:.|.||||||||:|.. :..|:.|.|....:...:||..|
Zfish   981 IVQPGRVFLKEGTLMKLSRKVMQPRMFFLFNDILLYTTPVQSGQYKVNSMLSLAGMKVSKPS--- 1042

  Fly    93 NQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCVEDLLRK-----SGKK-----------P 141
            .:.|:|...|.:..:||::.|.::||:.||:..|...::|..||     |.:.           |
Zfish  1043 QEAYQNELNIESVERSFILSANSATERDEWLEAIATAIDDYTRKKISFFSSRSQELEGISDDGLP 1107

  Fly   142 VENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKALRVCDA 206
            :.:.|.:|:||...::||.| ..:||...||||||.||.|||..||:.||.|.....:..||||.
Zfish  1108 LGSKAPIWIPDLRTTMCMIC-TCEFTLTWRRHHCRACGKVVCQACSSNKFYLEYLKNQLARVCDH 1171

  Fly   207 CYERLKHVPSSLGSGEDSAAATGAASGNKLNTTAGDSSNDEDSDEETASPGGESHDEPRFYGDNS 271
            ||.:|:|                          .||.||      .|.||.|.............
Zfish  1172 CYIKLQH--------------------------KGDQSN------VTFSPSGRGSTFAFSRKQKK 1204

  Fly   272 VLSAVEDSSTITSPSS 287
            :.||:::.|..|..||
Zfish  1205 IPSALKEVSANTENSS 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	36/100 (36%)
		PH	39..131	CDD:278594	33/92 (36%)
		FYVE_PKHF	148..208	CDD:277257	28/59 (47%)
fgd6	NP_001093450.1	DUF4775	<93..327	CDD:292620
		RhoGEF	773..957	CDD:279015
		PH-like	975..1097	CDD:302622	40/118 (34%)
		PH	990..1080	CDD:278594	33/92 (36%)
		FYVE_FGD6	1113..1173	CDD:277282	28/60 (47%)
		PH	1221..1313	CDD:278594	88/276 (32%)
		PH2_FGD5_FGD6	1221..1309	CDD:270057	88/276 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1729
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810