DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and plekhf2

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_001016121.1	Gene:	plekhf2 / 548875	XenbaseID:	XB-GENE-959911	Length:	248	Species:	Xenopus tropicalis

Alignment Length:	253	Identity:	154/253 - (60%)
Similarity:	191/253 - (75%)	Gaps:	7/253 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDRLVNSEANTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYG 65
            |||||.|||||::||..||:|||::|.|||:.||||:|||||||:|||:||:|||||||||||||
Frog     1 MVDRLANSEANSKRINLVESCFGTAGQPLAIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYG 65

  Fly    66 NIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCV 130
            ||||.|||||||||:|||.|::::|.|....||||.|:|.||||.|:|||:|||.|||.||||||
Frog    66 NIVIQKKKYNKQHIIPLENVTIDTIEDEGELRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCV 130

  Fly   131 EDLLRKSGKKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQ 195
            .||:.||||.|...|||||:||::|::||.|||.:||.:.||||||.||.|:|..||.|::|||.
Frog   131 CDLISKSGKTPNSEHAAVWIPDSEATICMRCKKVKFTPVNRRHHCRKCGYVICGPCSEKRYLLPS 195

  Fly   196 QSTKALRVCDACYERLKH--VPSSLGSGEDSAAATGAASGNKLNTTAGDSSNDEDSDE 251
            ||:|.:||||.||:.|.:  ..|.|.|..||.:....:..|     ..|..:||||.:
Frog   196 QSSKPVRVCDFCYDLLSNGDFSSCLPSRSDSFSHPSKSKNN-----LSDDDDDEDSSD 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	87/121 (72%)
		PH	39..131	CDD:278594	68/91 (75%)
		FYVE_PKHF	148..208	CDD:277257	35/59 (59%)
plekhf2	NP_001016121.1	PH_Phafin2-like	7..129	CDD:269927	87/121 (72%)
plekhf2	NP_001016121.1	FYVE_PKHF2	148..211	CDD:277294	37/62 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4397
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11620
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2460
OMA	1	1.010	-	-		QHG52283
OrthoDB	1	1.010	-	-		D1237900at2759
OrthoFinder	1	1.000	-	-		FOG0002686
OrthoInspector	1	1.000	-	-		oto104838
Panther	1	1.100	-	-	LDO	PTHR46280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	1	1.000	-	-		X3637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110