DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and Plekhf2

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_001102125.1	Gene:	Plekhf2 / 362484	RGDID:	1312029	Length:	249	Species:	Rattus norvegicus

Alignment Length:	256	Identity:	159/256 - (62%)
Similarity:	192/256 - (75%)	Gaps:	11/256 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDRLVNSEANTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYG 65
            |||||.|||||||||:.||:|||::|.||.:.||||:|||||||:|||:||:|||||||||||||
  Rat     1 MVDRLANSEANTRRISIVESCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYG 65

  Fly    66 NIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCV 130
            ||||.|||||||||:|||.|:::||.|....||||.|:|.||||.|:|||:|||.|||.||||||
  Rat    66 NIVIQKKKYNKQHIIPLENVTIDSIKDEGELRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCV 130

  Fly   131 EDLLRKSGKKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQ 195
            .|||.||||.|...||||||||::|:|||.|:|.:||.:.||||||.||.|||..||.|:||||.
  Rat   131 SDLLSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPS 195

  Fly   196 QSTKALRVCDACYERLKHVPSSLGSGEDSAAATGAAS---GNKLNTTAGDSSNDEDSDEET 253
            ||:|.:|:||.||:.|        |..|.||.....|   ...|.:...|:|:|:|.|:.:
  Rat   196 QSSKPVRICDFCYDLL--------STGDMAACQPTRSDSYSQSLKSPLNDASDDDDDDDSS 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	89/121 (74%)
		PH	39..131	CDD:278594	69/91 (76%)
		FYVE_PKHF	148..208	CDD:277257	37/59 (63%)
Plekhf2	NP_001102125.1	PH_Phafin2-like	7..129	CDD:269927	89/121 (74%)
		PH	39..131	CDD:278594	69/91 (76%)
		FYVE_PKHF2	148..211	CDD:277294	39/62 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352248
Domainoid	1	1.000	152	1.000	Domainoid score	I4238
eggNOG	1	0.900	-	-		E1_KOG1729
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11620
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2374
OMA	1	1.010	-	-		QHG52283
OrthoDB	1	1.010	-	-		D1237900at2759
OrthoFinder	1	1.000	-	-		FOG0002686
OrthoInspector	1	1.000	-	-		oto98152
orthoMCL	1	0.900	-	-		OOG6_105889
Panther	1	1.100	-	-	LDO	PTHR46280
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3637
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770