DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and Fyco1

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_001100340.1	Gene:	Fyco1 / 301085	RGDID:	1309069	Length:	1451	Species:	Rattus norvegicus

Alignment Length:	244	Identity:	59/244 - (24%)
Similarity:	94/244 - (38%)	Gaps:	58/244 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 KKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCVEDLLRK 136
            |||       |||..:|.:.|....   |.           .:.:.|.|:.::...||:.|:
  Rat  1107 KKY-------LEERLIELLRDKDAL---WQ-----------KSDALEFQQKLSAEEKCLGDM--- 1147

  Fly   137 SGKKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKAL 201
                             :|:.|..||: :|::|.||||||.||.:.|..| ...:::.:.|.|..
  Rat  1148 -----------------EANHCHDCKR-EFSWIVRRHHCRLCGRIFCYYC-CNNYVVTKPSGKKE 1193

  Fly   202 RVCDACYERLKHVPSSLGSGEDSAAATGAASGNKLNTTAGDSSNDEDSDEETASPGGESHDEPRF 266
            |.|.||:::.         ||.|.:...:.||......:...|..|.:.:...|.|......|
  Rat  1194 RCCRACFQKF---------GESSGSPDSSGSGTSQGEPSPMVSPAEAAPQSIGSQGINPVCRP-- 1247

  Fly   267 YGDNSVLSAVEDSSTITSPSSATTGSL-EAPQVTPSVQSSPAAVATTGS 314
             .|::|...:.|........|.:  || |.|..|.|:..:.|...||.:
  Rat  1248 -PDDAVFDIITDEELCQIQESGS--SLPETPTETDSMDPNMAEQDTTSN 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	11/56 (20%)
		PH	39..131	CDD:278594	13/58 (22%)
		FYVE_PKHF	148..208	CDD:277257	21/59 (36%)
Fyco1	NP_001100340.1	RUN	59..164	CDD:413440
		MukB	<237..>519	CDD:225638
		SMC_prok_B	392..>1117	CDD:274008	6/16 (38%)
		FYVE_FYCO1	1144..1200	CDD:277265	22/77 (29%)
		GOLD_2	<1392..1437	CDD:404736
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1729
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900