DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and Fgd5

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	XP_006506063.1	Gene:	Fgd5 / 232237	MGIID:	2443369	Length:	1515	Species:	Mus musculus

Alignment Length:	310	Identity:	77/310 - (24%)
Similarity:	127/310 - (40%)	Gaps:	55/310 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYGNIVIGKK--K 73
            |.:::..:|......| .|...||..:.||.|.::..|....|..||.||.|:|.:   .:|  |
Mouse  1142 NLQKLVHIEYSVRGQG-DLLQPGREFLKEGTLMRVRGKSRHPRHLFLMNDTLLYTH---PQKDGK 1202

  Fly    74 YNKQHIMPLEEVSL-ESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCV-EDLLRK 136
            |..:..:|:..:.: ..:.|...|  ...|.|......:.|::..|:.||...:::.: ||.  |
Mouse  1203 YRLKSSLPVANMKVSRPVMDKVPY--ALKIETPESCLTLSASSCAERDEWHYCLSRALPEDY--K 1263

  Fly   137 SGKKPVENHAA---------------VWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGC 186
            :......:|:.               ..||.|.|.:||:| ...|:...|||||..||.:||..|
Mouse  1264 TQALAAFHHSVEIRERLGISLGERLPTLVPVTHAMMCMNC-GCDFSLTVRRHHCHACGKIVCRNC 1327

  Fly   187 SAKKFLLPQQSTKALRVCDACYERLK----HVPSSLGSGEDS----AAATGAASGNKLNTTAGDS 243
            |..|:.|.....:..:|||.|:..||    .||.|:.....|    .:::..:||:.|::..
Mouse  1328 SRNKYPLKCLKNRMAKVCDGCFRELKLRNGPVPGSMRERPVSMSFPLSSSRFSSGSALSSVF--- 1389

  Fly   244 SNDEDSDEETASPGGESHDEPRFYGDNSVLSAVEDSSTITSPSSATTGSL 293
                    ::.||.       .|.....|.||:.:.:. :...||.:|.|
Mouse  1390 --------QSISPS-------TFKKQKKVPSALSEVAA-SGEGSAISGYL 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	29/120 (24%)
		PH	39..131	CDD:278594	23/95 (24%)
		FYVE_PKHF	148..208	CDD:277257	24/59 (41%)
Fgd5	XP_006506063.1	2A1904	<95..339	CDD:273344
		RhoGEF	946..1134	CDD:366202
		PH-like	1153..1275	CDD:388408	31/129 (24%)
		FYVE_like_SF	1289..1355	CDD:333710	27/66 (41%)
		PH2_FGD5_FGD6	1419..1509	CDD:270057	2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1729
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810