DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and Zfyve9

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	XP_006503049.1	Gene:	Zfyve9 / 230597	MGIID:	2652838	Length:	1431	Species:	Mus musculus

Alignment Length:	369	Identity:	89/369 - (24%)
Similarity:	137/369 - (37%)	Gaps:	99/369 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LVNSEANTRR-------IASVENCFGSSGVPLAMQGRVLVGEGVL-----TKMCRKRPKSRQFFL 57
            |:||..|..:       .:.:.:..|.|...:|....:.|..|..     :.:..:.||.....|
Mouse   541 LLNSTGNVMKKNYLHNFCSQIPSVLGQSSPKIANLQSISVPFGGARPKQPSNLKLQIPKPLSDHL 605

  Fly    58 FNDILVYG-------NIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRT-----TTKSFV 110
            .||:....       |.|:||.|..:...:.....:|.:|:...|  ||.::.|     :::..:
Mouse   606 QNDLPANNGNNSKNKNDVLGKAKLGENSAVNACSATLGNISVTDT--NGEHLETYEAEISSRPCL 668

  Fly   111 VFAATSTEKQEWMAHINKCVEDLLRK----SGKKP---VENHAAVWVPDTDASVCMHCKKTQFTF 168
            ..|..|.:            .||...    |.:||   :...|.|||||:.|..||.| :.:|||
Mouse   669 ALAPDSPD------------NDLRASQFGISARKPFTTLGEVAPVWVPDSQAPNCMKC-EARFTF 720

  Fly   169 IQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKALRVCDACYERLKHV-------------PSSLGS 220
            .:||||||.||.|.||.|.:.|..|.....|..|||..|:..|.:.             |:....
Mouse   721 TKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNP 785

  Fly   221 GE--------DSAAATGAASGNKLNTTAGDSSNDEDSDEETA--------SPGGE---SHDEPRF 266
            .|        ..|.|:||.|                |...|.        .||.|   ..::.|.
Mouse   786 AEYCSTIPPLQQAQASGALS----------------SPPPTVMVPVGVLKHPGTEVPQPREQRRV 834

  Fly   267 YGDNSVL--SAVEDSSTITSPSSATTGSLEAPQ--VTPSVQSSP 306
            :..:.:|  ..|.|::.:|...:::.|:|....  |.| |.:||
Mouse   835 WFADGILPNGEVADAAKLTMNGTSSAGTLAVSHDPVKP-VATSP 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	26/145 (18%)
		PH	39..131	CDD:278594	19/108 (18%)
		FYVE_PKHF	148..208	CDD:277257	30/59 (51%)
Zfyve9	XP_006503049.1	FYVE_endofin	696..763	CDD:277268	32/67 (48%)
		SARA	779..817	CDD:371513	9/53 (17%)
		DUF3480	1054..1406	CDD:371829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940