DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and Zfyve16

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_775568.1	Gene:	Zfyve16 / 218441	MGIID:	2145181	Length:	1528	Species:	Mus musculus

Alignment Length:	255	Identity:	71/255 - (27%)
Similarity:	97/255 - (38%)	Gaps:	86/255 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 KKYNKQHIMPLEE-------------VSLESIADNQTYRNGWYIRTTT-----KSFVVFAATSTE 118
            |:.||..::.:.|             .|.:.|.|:|...|..||...:     .|||.....|..
Mouse   651 KELNKPDVVDVPESEPCTANATAVSTCSADHIPDSQVSFNSNYIDIESNFEDGSSFVTANKDSLP 715

  Fly   119 KQEWMAHINKCVEDLLRKSGKKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVC 183
            :       ||..|.|: ...|:|      .||||::|..||:| :.:|||.:||||||.||.|.|
Mouse   716 E-------NKRKESLV-LGQKQP------TWVPDSEAPNCMNC-QVKFTFTKRRHHCRACGKVFC 765

  Fly   184 AGCSAKKFLLPQQSTKALRVCDACYERLKHVPSSLGSGEDSAAATGAASGNKLNTTAGDSSNDED 248
            ..|..:|..| |...|..|||..|||.:                                 |...
Mouse   766 GVCCNRKCKL-QYLEKEARVCVICYETI---------------------------------NKAQ 796

  Fly   249 SDEETASPGG----ESH------DEPRFYGDNSVLSAVEDSSTITSPSSATTGSLEAPQV 298
            :.|...||||    .:|      |:|        |...:.||| .||::....:|:.|.|
Mouse   797 AFERMMSPGGSCLKSNHSNECATDQP--------LQETQTSST-PSPTTLPISALKQPNV 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	16/74 (22%)
		PH	39..131	CDD:278594	17/76 (22%)
		FYVE_PKHF	148..208	CDD:277257	29/59 (49%)
Zfyve16	NP_775568.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..664		3/12 (25%)
		FYVE_endofin	726..792	CDD:277268	34/73 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..849		11/38 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	928..949
		DUF3480	1155..1503	CDD:288806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940