Protein Alignment rush and FGD5

DIOPT Version :10

• Sequence 1: NP_569923.2
• Gene: rush / 31105
• FlyBaseID: FBgn0025381
• Length: 316
• Species: Drosophila melanogaster
• Sequence 2: XP_011531724.2
• Gene: FGD5 / 152273
• HGNCID: 19117
• Length: 1507
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 73/319 - (22%)
• Similarity: 124/319 - (38%)
• Gaps: 79/319 - (24%)

  Fly    11 NTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYGNIVIGKK--K 73
            |.:::..:|:.....| .|...||..:.||.|.|:..|..:.|..||.||:|:|   ...:|  |
Human  1133 NLQKLVHIEHSVRGQG-DLLQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVLLY---TYPQKDGK 1193

  Fly    74 YNKQHIMPLEEVSL-ESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCV-EDLLRK 136
            |..::.:.:..:.: ..:.:...|  ...|.|:....::.|::..|:.||...:::.: ||...:
Human  1194 YRLKNTLAVANMKVSRPVMEKVPY--ALKIETSESCLMLSASSCAERDEWYGCLSRALPEDYKAQ 1256

  Fly   137 S------------------GKKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVC 183
            :                  |::|     ...||.|...:||:| ...|:...|||||..||.:||
Human  1257 ALAAFHHSVEIRERLGVSLGERP-----PTLVPVTHVMMCMNC-GCDFSLTLRRHHCHACGKIVC 1315

  Fly   184 AGCSAKKFLLPQQSTKALRVCDACYERLKH----VPSSLGSGEDSAAATGAASGNKLNTTAGDSS 244
            ..||..|:.|.....:..:|||.|:..||.    ||..:...|...:.:...|
Human  1316 RNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRAVPGLMRVTERPVSMSFPLS------------ 1368

  Fly   245 NDEDSDEETASPGGESHDEPRFYGD--NSVLSAVEDS---------STITSPSSATTGS 292
                              .|||.|.  :||..::..|         |.:|..:::..||
Human  1369 ------------------SPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEGS 1409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_569923.2	PH_Phafin2-like	7..129	CDD:269927	28/120 (23%)
		FYVE_PKHF	148..208	CDD:277257	23/59 (39%)
FGD5	XP_011531724.2	PHA03169	175..>366	CDD:223003
		RhoGEF	939..1125	CDD:459876
		PH1_FGD5	1144..1266	CDD:275435	28/127 (22%)
		FYVE_FGD5	1280..1346	CDD:277281	26/66 (39%)
		PH2_FGD5_FGD6	1411..1501	CDD:270057