DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and Fgd6

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	XP_036011484.1	Gene:	Fgd6 / 13998	MGIID:	1261419	Length:	1401	Species:	Mus musculus

Alignment Length:	256	Identity:	75/256 - (29%)
Similarity:	122/256 - (47%)	Gaps:	38/256 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LAMQGR--VLVGEGVLTKMCRKRPKSRQFFLFNDILVYGNIVIGKKKYNKQHIMPLEEVSLESIA 91
            :...||  |.:.||.|.|:.||..:.|.||||||.|:| ...:....|...:::.|..:.:.. .
Mouse  1053 IVQPGRNDVFLKEGTLMKLSRKVMQPRMFFLFNDALLY-TTPMQSGMYKLNNMLSLAGMKVRK-P 1115

  Fly    92 DNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCV-----------------EDLLRKSGK 139
            ..:.|:|...|.:..:||::.|:::.|:.:|:..|:..:                 ||..||...
Mouse  1116 TQEAYQNELKIESVERSFILSASSAAERDDWLEAISSSIEEYAKKRITFCPSRSLDEDSERKEEV 1180

  Fly   140 KPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKALRVC 204
            .|:...|.:|:|||.|::||.| .::||...||||||.||.:||..||:.|:.|.....:..|||
Mouse  1181 SPLGAKAPIWIPDTRATMCMIC-TSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKGQLARVC 1244

  Fly   205 DACYERLKHVPSSL-------GSGEDSAAATGAA-----SGNKLNTTAGD----SSNDEDS 249
            :.|::.|:.:...|       |:.:..::|..:.     ||.|.......    |:|.|||
Mouse  1245 EHCFQELQKLDHQLSPRVGSPGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDS 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	29/101 (29%)
		PH	39..131	CDD:278594	26/108 (24%)
		FYVE_PKHF	148..208	CDD:277257	27/59 (46%)
Fgd6	XP_036011484.1	RhoGEF	845..1028	CDD:395496
		PH-like	1047..1171	CDD:418428	29/119 (24%)
		FYVE_FGD6	1188..1248	CDD:277282	27/60 (45%)
		PH2_FGD5_FGD6	1307..1395	CDD:270057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1729
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810