DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rush and fgd5b

DIOPT Version :9

Sequence 1:	NP_001284784.1	Gene:	rush / 31105	FlyBaseID:	FBgn0025381	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_001352385.1	Gene:	fgd5b / 101884144	ZFINID:	ZDB-GENE-130925-3	Length:	1299	Species:	Danio rerio

Alignment Length:	230	Identity:	70/230 - (30%)
Similarity:	105/230 - (45%)	Gaps:	33/230 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DRLVNSEANTRRIASVE-NCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVY-- 64
            |.|.|. |:..|:..:| :..|.:  .|...|||.|.||.|.|:.||..:.|..||.|||::|
Zfish   944 DSLKNG-ADLMRLVHIEHSVLGLT--DLIQPGRVFVKEGTLMKVSRKCKQPRHLFLMNDIMLYTY 1005

  Fly    65 ----GNIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAH 125
                |       ||...:.:||..:.: |....::.::...|.....|..:.|::..|:..|...
Zfish  1006 PQQDG-------KYRLINRLPLAGMKV-SKPPMESAQSAIKIEVKDISITLSASSCIERDGWFVT 1062

  Fly   126 INKCVEDLLRKSGKKPVENHAAVWVPD-------------TDASVCMHCKKTQFTFIQRRHHCRN 177
            :|:.:.||...|| .||::...|..|:             :..:|||:| .:.|:...|||||..
Zfish  1063 MNRTLVDLGSASG-DPVDSFELVESPEKCLGENAPPLLSVSQVTVCMNC-PSHFSLTNRRHHCHA 1125

  Fly   178 CGAVVCAGCSAKKFLLPQQSTKALRVCDACYERLK 212
            ||.|||..|...||.|.....:..:|||.||..|:
Zfish  1126 CGKVVCRDCCRNKFPLKYMKNRRAKVCDHCYTELR 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rush	NP_001284784.1	PH_Phafin2-like	7..129	CDD:269927	35/128 (27%)
		PH	39..131	CDD:278594	25/97 (26%)
		FYVE_PKHF	148..208	CDD:277257	24/72 (33%)
fgd5b	NP_001352385.1	RhoGEF	791..939	CDD:238091
		PH-like	962..1069	CDD:327399	31/116 (27%)
		FYVE_like_SF	1096..1161	CDD:333710	25/66 (38%)
		PH2_FGD5_FGD6	1207..1293	CDD:270057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002686
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910