Protein Alignment Rab27 and RAB5C

DIOPT Version :10

• Sequence 1: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Sequence 2: NP_001238968.1
• Gene: RAB5C / 5878
• HGNCID: 9785
• Length: 249
• Species: Homo sapiens
• Alignment Length: 258
• Identity: 72/258 - (27%)
• Similarity: 114/258 - (44%)
• Gaps: 51/258 - (19%)

  Fly     1 MRAAPPEPEPL-------QLAGSGE--------------QF--LVLGDSGVGKTCLLYQYTDGRF 42
            :.:..|.|..|       .:||.|.              ||  ::||:|.|||:.|:.::..|:|
Human    15 LHSTSPHPHALWTTTAGRAMAGRGGAARPNGPAAGNKICQFKLVLLGESAVGKSSLVLRFVKGQF 79

  Fly    43 HTQFISTVGIDFREKRLLYNSRGRRHRIHLQIWDTAGQERFRSLTTAFYRDAMGFLLIFDLTSEK 107
            |....||:|..|..:.:..:..    .:..:|||||||||:.||...:||.|...::::|:|:..
Human    80 HEYQESTIGAAFLTQTVCLDDT----TVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTD 140

  Fly   108 SFLETANWLSQLRTHAYSEDPDVV--LCGNKCDLLQLRVVSRDQVAALCRRYRLPYIETSACTGA 170
            :|....||:.:|:..|   .|::|  |.|||.||...|.|...:..|......|.::||||.|..
Human   141 TFARAKNWVKELQRQA---SPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAM 202

  Fly   171 NVKEAVELLVGRVMERIENAACNREFSLLLTQSRCLPNIAYGQPEDLVRLHDRREEPCSRRNC 233
            ||.| :.:.:.:.:.:.|                  |..|.|.|.....:..:...|.||..|
Human   203 NVNE-IFMAIAKKLPKNE------------------PQNATGAPGRNRGVDLQENNPASRSQC 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	57/171 (33%)
RAB5C	NP_001238968.1	Rab5_related	54..216	CDD:206653	57/169 (34%)