DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab27 and RAB27B

DIOPT Version :9

Sequence 1:	NP_726743.1	Gene:	Rab27 / 31103	FlyBaseID:	FBgn0025382	Length:	236	Species:	Drosophila melanogaster
Sequence 2:	NP_001362256.1	Gene:	RAB27B / 5874	HGNCID:	9767	Length:	218	Species:	Homo sapiens

Alignment Length:	176	Identity:	106/176 - (60%)
Similarity:	136/176 - (77%)	Gaps:	6/176 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYN------SRGRRHRIHLQIWDT 77
            :.|.|||||||||..||:|||.:|:.:||:||||||||||::||      |.|:..::|||:|||
Human    11 KLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGKAFKVHLQLWDT 75

  Fly    78 AGQERFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQL 142
            |||||||||||||:||||||||:|||||::|||...||:|||:.:||.|:||:||.|||.||...
Human    76 AGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPDQ 140

  Fly   143 RVVSRDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIE 188
            |.|:..|...|..:|.:||.||||.||.||::|||.|:..:|:|:|
Human   141 REVNERQARELADKYGIPYFETSAATGQNVEKAVETLLDLIMKRME 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop_NTPase	19..187	CDD:304359	104/173 (60%)
Rab27	NP_726743.1	RAB	20..186	CDD:197555	104/171 (61%)
RAB27B	NP_001362256.1	Rab27A	6..185	CDD:206700	104/173 (60%)
		Effector region. /evidence=ECO:0000250	38..46		6/7 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..218
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2493
eggNOG	1	0.900	-	-		E1_KOG0081
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3403
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1190514at2759
OrthoFinder	1	1.000	-	-		FOG0004299
OrthoInspector	1	1.000	-	-		otm42024
orthoMCL	1	0.900	-	-		OOG6_105898
Panther	1	1.100	-	-	O	PTHR47977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3032
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830