Protein Alignment Rab27 and RAB27A

DIOPT Version :10

• Sequence 1: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Sequence 2: NP_004571.2
• Gene: RAB27A / 5873
• HGNCID: 9766
• Length: 221
• Species: Homo sapiens
• Alignment Length: 207
• Identity: 116/207 - (56%)
• Similarity: 149/207 - (71%)
• Gaps: 23/207 - (11%)

  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLY------NSRGRRHRIHLQIWDT 77
            :||.|||||||||.:|||||||:|:::||:||||||||||::|      .:.||..|||||:|||
Human    11 KFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRASGPDGATGRGQRIHLQLWDT 75

  Fly    78 AGQERFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQL 142
            |||||||||||||:||||||||:||||:|:|||...||:|||:.|||.|:||:||||||.||...
Human    76 AGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQ 140

  Fly   143 RVVSRDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREFSLLLTQSRCLP 207
            |||..::..||..:|.:||.||||..|.|:.:|:|:|:..:|:|:|               ||:.
Human   141 RVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEMLLDLIMKRME---------------RCVD 190

  Fly   208 NIAYGQPEDLVR 219
            ....  ||.:||
Human   191 KSWI--PEGVVR 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	108/173 (62%)
RAB27A	NP_004571.2	Rab27A	6..185	CDD:206700	108/173 (62%)
		Effector region. /evidence=ECO:0000250	38..46		6/7 (86%)