Protein Alignment Rab27 and RAB4A

DIOPT Version :10

• Sequence 1: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Sequence 2: NP_004569.2
• Gene: RAB4A / 5867
• HGNCID: 9781
• Length: 218
• Species: Homo sapiens
• Alignment Length: 215
• Identity: 78/215 - (36%)
• Similarity: 123/215 - (57%)
• Gaps: 13/215 - (6%)

  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRHRIHLQIWDTAGQERF 83
            :|||:|::|.||:|||:|:.:.:|......|:|::|..|  :.|..|:  .:.||||||||||||
Human    15 KFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSK--IINVGGK--YVKLQIWDTAGQERF 75

  Fly    84 RSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQLRVVSRD 148
            ||:|.::||.|.|.||::|:||.:::....|||:..|..| |::..::|||||.||...|.|:..
Human    76 RSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLA-SQNIVIILCGNKKDLDADREVTFL 139

  Fly   149 QVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREFSLLLTQSRCLPNIAYGQ 213
            :.:...:...|.::||||.||.||:||......:::.:||:...:.|        |....|.||.
Human   140 EASRFAQENELMFLETSALTGENVEEAFVQCARKILNKIESGELDPE--------RMGSGIQYGD 196

  Fly   214 PEDLVRLHDRREEPCSRRNC 233
            .........||.:..:.:.|
Human   197 AALRQLRSPRRAQAPNAQEC 216

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	68/167 (41%)
RAB4A	NP_004569.2	Rab4	14..174	CDD:206696	68/163 (42%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	44..49		2/4 (50%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	70..79		8/8 (100%)