Protein Alignment Rab27 and RAB3B

DIOPT Version :10

• Sequence 1: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Sequence 2: NP_002858.2
• Gene: RAB3B / 5865
• HGNCID: 9778
• Length: 219
• Species: Homo sapiens
• Alignment Length: 217
• Identity: 83/217 - (38%)
• Similarity: 130/217 - (59%)
• Gaps: 25/217 - (11%)

  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRH--RIHLQIWDTAGQE 81
            :.|::|:|.||||..|::|.|..|...|:|||||||:.|.:.      ||  |:.||||||||||
Human    24 KLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVY------RHEKRVKLQIWDTAGQE 82

  Fly    82 RFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQLRVVS 146
            |:|::|||:||.||||:|::|:|:|:||....:|.:|::|::: ::..|:|.|||||:.:.|||.
Human    83 RYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSW-DNAQVILVGNKCDMEEERVVP 146

  Fly   147 RDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREFSLLLTQSRCLPNIAY 211
            .::...|..:....:.|.||....:|::|        .||:.:|.|::....|.|....|
Human   147 TEKGQLLAEQLGFDFFEASAKENISVRQA--------FERLVDAICDKMSDSLDTDPSML----- 198

  Fly   212 GQPEDLVRLHDRREEPCSRRNC 233
            |..:: .||.|  ..|..::||
Human   199 GSSKN-TRLSD--TPPLLQQNC 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	70/169 (41%)
RAB3B	NP_002858.2	Rab3	22..186	CDD:206657	73/176 (41%)
		Switch 1. /evidence=ECO:0000269|PubMed:35871249, ECO:0007744|PDB:8A4B	45..58		6/12 (50%)
		Switch 2. /evidence=ECO:0000269|PubMed:35871249, ECO:0007744|PDB:8A4B	78..96		12/17 (71%)