Protein Alignment Rab27 and Rab37

DIOPT Version :10

• Sequence 1: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Sequence 2: NP_067386.3
• Gene: Rab37 / 58222
• MGIID: 1929945
• Length: 223
• Species: Mus musculus
• Alignment Length: 228
• Identity: 90/228 - (39%)
• Similarity: 126/228 - (55%)
• Gaps: 27/228 - (11%)

  Fly     4 APPEPEPLQLAGSGEQFLVLGDSGVGKTCLLYQYTDGRFHT-QFISTVGIDFREKRLLYNSRGRR 67
            :||......|.|   :.::||||||||||.|.|:.||.|.: .||:|||||||.|.:..:..
Mouse    19 SPPFSPNYDLTG---KVMLLGDSGVGKTCFLIQFKDGAFLSGTFIATVGIDFRNKVVTVDGA--- 77

  Fly    68 HRIHLQIWDTAGQERFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSE-DPDVV 131
             |:.||||||||||||||:|.|:||||...||::|:|::.||.....||:::  |.|:: |..::
Mouse    78 -RVKLQIWDTAGQERFRSVTHAYYRDAQALLLLYDITNQSSFDNIRAWLTEI--HEYAQRDVVIM 139

  Fly   132 LCGNKCDLLQLRVVSRDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREF 196
            |.|||.|:...||:..:....|.|.|.:|::||||.||.||:.|...:...:..|     ..|:
Mouse   140 LLGNKADVSSERVIRSEDGETLAREYGVPFMETSAKTGMNVELAFLAIAKELKYR-----AGRQ- 198

  Fly   197 SLLLTQSRCLPNIAYGQPEDLVRLHDRREEPCS 229
                      |:....|..|.|....:|...||
Mouse   199 ----------PDEPSFQIRDYVESQKKRSSCCS 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	77/169 (46%)
Rab37	NP_067386.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		1/2 (50%)
		Rab26	31..220	CDD:206695	84/210 (40%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	52..67		8/14 (57%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	85..102		13/16 (81%)