Protein Alignment Rab27 and RAB8A

DIOPT Version :10

• Sequence 1: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Sequence 2: NP_005361.2
• Gene: RAB8A / 4218
• HGNCID: 7007
• Length: 207
• Species: Homo sapiens
• Alignment Length: 170
• Identity: 74/170 - (43%)
• Similarity: 116/170 - (68%)
• Gaps: 5/170 - (2%)

  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRHRIHLQIWDTAGQERF 83
            :.|::|||||||||:|:::::..|::.||||:||||:.:.:..:.:    ||.||||||||||||
Human    10 KLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGK----RIKLQIWDTAGQERF 70

  Fly    84 RSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQLRVVSRD 148
            |::|||:||.|||.:|::|:|:||||....||:..:..|| |.|.:.::.|||||:...|.||::
Human    71 RTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHA-SADVEKMILGNKCDVNDKRQVSKE 134

  Fly   149 QVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIE 188
            :...|...|.:.::||||....||:.|...|...:..:::
Human   135 RGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMD 174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	74/167 (44%)
RAB8A	NP_005361.2	Rab8_Rab10_Rab13_like	6..172	CDD:206659	74/166 (45%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	31..45		7/13 (54%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	63..80		13/16 (81%)