Protein Alignment Rab27 and RAB37

DIOPT Version :10

• Sequence 1: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Sequence 2: NP_001006639.1
• Gene: RAB37 / 326624
• HGNCID: 30268
• Length: 223
• Species: Homo sapiens
• Alignment Length: 228
• Identity: 89/228 - (39%)
• Similarity: 125/228 - (54%)
• Gaps: 27/228 - (11%)

  Fly     4 APPEPEPLQLAGSGEQFLVLGDSGVGKTCLLYQYTDGRFHT-QFISTVGIDFREKRLLYNSRGRR 67
            :||......|.|   :.::|||:||||||.|.|:.||.|.: .||:|||||||.|.:..:.
Human    19 SPPCSPSYDLTG---KVMLLGDTGVGKTCFLIQFKDGAFLSGTFIATVGIDFRNKVVTVDG---- 76

  Fly    68 HRIHLQIWDTAGQERFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSE-DPDVV 131
            .|:.||||||||||||||:|.|:||||...||::|:|::.||.....||:::  |.|:: |..::
Human    77 VRVKLQIWDTAGQERFRSVTHAYYRDAQALLLLYDITNKSSFDNIRAWLTEI--HEYAQRDVVIM 139

  Fly   132 LCGNKCDLLQLRVVSRDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREF 196
            |.|||.|:...||:..:....|.|.|.:|::||||.||.||:.|...:...:..|..:.|....|
Human   140 LLGNKADMSSERVIRSEDGETLAREYGVPFLETSAKTGMNVELAFLAIAKELKYRAGHQADEPSF 204

  Fly   197 SLLLTQSRCLPNIAYGQPEDLVRLHDRREEPCS 229
                            |..|.|....:|...||
Human   205 ----------------QIRDYVESQKKRSSCCS 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	76/169 (45%)
RAB37	NP_001006639.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		2/3 (67%)
		Rab26	31..220	CDD:206695	83/210 (40%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	52..67		8/14 (57%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	85..102		13/16 (81%)