Protein Alignment Rab27 and RAB26

DIOPT Version :10

• Sequence 1: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Sequence 2: NP_055168.2
• Gene: RAB26 / 25837
• HGNCID: 14259
• Length: 256
• Species: Homo sapiens
• Alignment Length: 237
• Identity: 96/237 - (40%)
• Similarity: 127/237 - (53%)
• Gaps: 44/237 - (18%)

  Fly     4 APPEPEPLQ----LAGSGEQF-------LVLGDSGVGKTCLLYQYTDGRFHT-QFISTVGIDFRE 56
            |||. .|||    ..|.|..|       :::|||||||||||.::.||.|.. .||||||||||.
Human    40 APPN-GPLQPGRPSLGGGVDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRN 103

  Fly    57 KRLLYNSRGRRHRIHLQIWDTAGQERFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRT 121
            |.|..:.    .::.||:|||||||||||:|.|:||||...||::|:|::.||.....||:::
Human   104 KVLDVDG----VKVKLQMWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKASFDNIQAWLTEI-- 162

  Fly   122 HAYSE-DPDVVLCGNKCDLLQLRVVSRDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVME 185
            |.|:: |..::|.|||.|....|||.|:....|.:.|.||::||||.||.||..|...:...:.:
Human   163 HEYAQHDVALMLLGNKVDSAHERVVKREDGEKLAKEYGLPFMETSAKTGLNVDLAFTAIAKELKQ 227

  Fly   186 RIENAACNREFSLLLTQSRCLPNIAYGQPEDLVRLHD--RRE 225
            |...|.....|                      ||||  :||
Human   228 RSMKAPSEPRF----------------------RLHDYVKRE 247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	79/176 (45%)
RAB26	NP_055168.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		6/11 (55%)
		Rab26	64..254	CDD:206695	87/212 (41%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	86..101		9/14 (64%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	119..136		13/16 (81%)