DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab27 and aex-6

DIOPT Version :9

Sequence 1:	NP_726743.1	Gene:	Rab27 / 31103	FlyBaseID:	FBgn0025382	Length:	236	Species:	Drosophila melanogaster
Sequence 2:	NP_493376.1	Gene:	aex-6 / 173223	WormBaseID:	WBGene00000089	Length:	215	Species:	Caenorhabditis elegans

Alignment Length:	223	Identity:	112/223 - (50%)
Similarity:	142/223 - (63%)	Gaps:	21/223 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSR-----GRRHRIHLQIWDTA 78
            :||.|||||||||..|::|||..|..||||||||||:||:::|.|.     ||..|:.||:||||
Worm     9 KFLALGDSGVGKTSFLHRYTDNTFTGQFISTVGIDFKEKKVVYKSSRGGFGGRGQRVLLQLWDTA 73

  Fly    79 GQERFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQLR 143
            ||||||||||||:||||||:||||:|:|:|||...:|||||:.|||.|.||:::||||.||...|
Worm    74 GQERFRSLTTAFFRDAMGFILIFDITNEQSFLNIRDWLSQLKVHAYCEQPDIIICGNKADLENRR 138

  Fly   144 VVSRDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREFSLLLTQSRCLPN 208
            .||..:...|..:..|||.||||||..||:::|:.|:..||:||:.:.......|    |.|...
Worm   139 QVSTARAKQLADQLGLPYFETSACTSTNVEKSVDCLLDLVMQRIQQSVETSSLPL----SECRGV 199

  Fly   209 IAYGQPEDLVRLHDRREEPCSRRNCRNC 236
            ...|.|.            .:...|.||
Worm   200 SLDGDPS------------AASSYCANC 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop_NTPase	19..187	CDD:304359	102/172 (59%)
Rab27	NP_726743.1	RAB	20..186	CDD:197555	102/170 (60%)
aex-6	NP_493376.1	Rab27A	4..182	CDD:206700	102/172 (59%)
aex-6	NP_493376.1	Ras	9..180	CDD:278499	101/170 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159887
Domainoid	1	1.000	205	1.000	Domainoid score	I1715
eggNOG	1	0.900	-	-		E1_KOG0081
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3069
Inparanoid	1	1.050	213	1.000	Inparanoid score	I2357
Isobase	1	0.950	-	0	Normalized mean entropy	S608
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1190514at2759
OrthoFinder	1	1.000	-	-		FOG0004299
OrthoInspector	1	1.000	-	-		oto20001
orthoMCL	1	0.900	-	-		OOG6_105898
Panther	1	1.100	-	-	LDO	PTHR47977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3121
SonicParanoid	1	1.000	-	-		X3032
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.780