DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab27 and Rab27a

DIOPT Version :9

Sequence 1:	NP_726743.1	Gene:	Rab27 / 31103	FlyBaseID:	FBgn0025382	Length:	236	Species:	Drosophila melanogaster
Sequence 2:	NP_001288159.1	Gene:	Rab27a / 11891	MGIID:	1861441	Length:	221	Species:	Mus musculus

Alignment Length:	207	Identity:	114/207 - (55%)
Similarity:	146/207 - (70%)	Gaps:	23/207 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSR------GRRHRIHLQIWDT 77
            :||.|||||||||.:|||||||:|:::||:||||||||||::|.:.      ||..|||||:|||
Mouse    11 KFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRANGPDGAVGRGQRIHLQLWDT 75

  Fly    78 AGQERFRSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQL 142
            |||||||||||||:||||||||:||||:|:|||...||:|||:.|||.|:||:||||||.||...
Mouse    76 AGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQ 140

  Fly   143 RVVSRDQVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREFSLLLTQSRCLP 207
            |.|..::...|..:|.:||.||||..|.|:..|:|:|:..:|:|:|               ||:.
Mouse   141 RAVKEEEARELAEKYGIPYFETSAANGTNISHAIEMLLDLIMKRME---------------RCVD 190

  Fly   208 NIAYGQPEDLVR 219
            ....  ||.:||
Mouse   191 KSWI--PEGVVR 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab27	NP_726743.1	P-loop_NTPase	19..187	CDD:304359	106/173 (61%)
Rab27	NP_726743.1	RAB	20..186	CDD:197555	106/171 (62%)
Rab27a	NP_001288159.1	Rab27A	6..185	CDD:206700	106/173 (61%)
Rab27a	NP_001288159.1	Effector region. /evidence=ECO:0000250	38..46		6/7 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838017
Domainoid	1	1.000	225	1.000	Domainoid score	I2526
eggNOG	1	0.900	-	-		E1_KOG0081
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3069
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3417
Isobase	1	0.950	-	0	Normalized mean entropy	S608
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004299
OrthoInspector	1	1.000	-	-		otm44076
orthoMCL	1	0.900	-	-		OOG6_105898
Panther	1	1.100	-	-	LDO	PTHR47977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3121
SonicParanoid	1	1.000	-	-		X3032
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.730