Protein Alignment CG14780 and KLKB1

DIOPT Version :10

• Sequence 1: NP_569920.2
• Gene: CG14780 / 31102
• FlyBaseID: FBgn0025383
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: XP_011530232.1
• Gene: KLKB1 / 3818
• HGNCID: 6371
• Length: 649
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 87/287 - (30%)
• Similarity: 125/287 - (43%)
• Gaps: 47/287 - (16%)

  Fly     4 FGLHGCSYILFWFLLACAAAD---LQENQQSRIINGSVAKADETRHLVSIRLLRHDNNFGSGHIC 65
            :|..|.|   .:.|..|...|   ......:||:.|:.:...|....||:::    ......|:|
Human   373 YGTQGSS---GYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQV----KLTAQRHLC 430

  Fly    66 GGALIAPRKVLTAAHCLYNNQRKRFRRASEFVVVLGTLNRFEHRNGTIVSQVSSMAYMHTFSPDS 130
            ||:||..:.|||||||......:...|     :..|.||..:....|..||:..:.....:....
Human   431 GGSLIGHQWVLTAAHCFDGLPLQDVWR-----IYSGILNLSDITKDTPFSQIKEIIIHQNYKVSE 490

  Fly   131 MRDDVGILFLRTGLPMSPGGGVHLTVAPI---QLAGQITPPGK--------LCQVAGWG-RTEQS 183
            ...|:.::.|:               ||:   :....|..|.|        .|.|.||| ..|:.
Human   491 GNHDIALIKLQ---------------APLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKG 540

  Fly   184 SLSNILLTANVSTIRHQTCRMIYRS-GLLPGMMCAGRLQGGTDSCQGDSGGPLV--HEG--RLVG 243
            .:.|||...|:..:.::.|:..|:. .:...|:|||..:||.|:|:||||||||  |.|  ||||
Human   541 EIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVG 605

  Fly   244 VVSWGYGCAEPGLPGVYVDVEYYRQWI 270
            :.|||.|||....||||..|..|..||
Human   606 ITSWGEGCARREQPGVYTKVAEYMDWI 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14780	NP_569920.2	Tryp_SPc	33..271	CDD:238113	80/255 (31%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519	4/15 (27%)
		Tryp_SPc	402..632	CDD:238113	78/253 (31%)